Integrated Receiver for Continuous Glucose Sensor Calibration
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Solution Overview
Problem
Existing continuous glucose sensors require frequent calibration with reference glucose measurements, often using separate devices that are cumbersome and prone to human error, and have inaccuracies due to different measurement technologies.
Innovation Solution
A device with an integrated receiver that includes a continuous glucose sensor and a single point glucose monitor, where the receiver processes data from both to calibrate the sensor stream, using an electrochemical cell with an enzyme-based sensing membrane for accurate glucose measurement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If continuous glucose sensors are calibrated using separate reference glucose monitor devices, then calibration can be performed, but device complexity and ease of operation deteriorate due to multiple separate devices and auxiliary hardware
Solution Approach 1:
The patent combines the continuous glucose sensor and the reference glucose monitor into a single integrated device. The receiver unit receives data from both the continuous sensor and the single-point reference monitor, performing calibration internally. This merging eliminates the need for separate devices and auxiliary cables, directly resolving the contradiction by maintaining calibration accuracy while reducing system complexity.
Solution Approach 2:
The integrated receiver unit serves multiple functions: it continuously receives and processes data from the implantable sensor, performs reference glucose measurements using an integrated single-point monitor, and executes calibration algorithms. This multi-functionality allows a single device to replace multiple separate devices, improving ease of operation while maintaining measurement precision.
2Measurement precision
If separate reference glucose monitor devices are used for calibration, then calibration can be performed, but ease of operation worsens due to user burden of carrying and managing multiple devices
Solution Approach 1:
By integrating the reference glucose monitor within the receiver unit that the user already carries for continuous monitoring, the patent eliminates the need to carry and manage separate calibration devices. The user interacts with a single unified device for both continuous monitoring and calibration, significantly improving ease of operation while preserving calibration capability.
Solution Approach 2:
The integrated system performs calibration automatically using its own built-in reference monitor. The receiver unit self-calibrates by comparing continuous sensor data against measurements from its integrated single-point monitor, reducing user burden and improving ease of operation without sacrificing calibration accuracy.
3Adaptability or versatility
If different measurement technologies are used for continuous sensor and reference monitor, then calibration can be performed, but measurement precision deteriorates due to increased error in calibrated values
Solution Approach 1:
The patent employs algorithms that detect and compensate for systematic biases between the continuous sensor and reference monitor measurements. By dynamically adjusting calibration parameters based on comparative analysis of data from both sensors, the system maintains calibration flexibility while minimizing measurement precision errors caused by technological differences.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces errors and human intervention, providing a user-friendly, accurate, and less cumbersome method for continuous glucose monitoring with improved calibration accuracy.
Implementation Method 1
The continuous glucose sensor comprises a sensing membrane comprising an enzyme; and an electrochemical cell that measures the glucose concentration
Implementation Method 2
an electrochemical cell that measures the glucose concentration
Data Source
AI summary
A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.