Integrated Liquid Specimen Lysis Detection With Sealing-Film Piercing
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Solution Overview
Problem
Existing liquid specimen detection devices face issues with insufficient saliva volume for testing due to complex mixing processes with lysis solution, leading to contamination risks and inefficient use of specimen, and require large vial structures for reagents, hindering miniaturization.
Innovation Solution
A liquid specimen lysis detection device integrating a sampling detection unit, lysis unit, and detachable limit structure, allowing for miniaturized design with automatic lysis and sample addition through a capped pen-style structure, featuring a piercing sleeve to puncture sealing films and prevent specimen loss.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If a lysis solution is employed to lyse liquid specimens, then the specimen volume requirement is met, but the mixing process becomes complex and increases contamination risk
Solution Approach 1:
The patent combines the sample collection, lysis, and detection functions into a single integrated device. The collection tube serves both as the sampling container and the lysis reaction vessel, eliminating the need for separate mixing steps and reducing contamination risk while ensuring adequate specimen volume for testing.
Solution Approach 2:
The collection tube is designed to perform multiple functions: it collects the liquid specimen, contains the lysis solution, facilitates mixing through its structural design, and serves as the reaction vessel for detection. This multi-functionality simplifies the overall process while maintaining specimen volume requirements.
2Quantity of substance
If a bottle structure is used for storing reagent strips, then reagent storage is achieved, but the overall device size increases
Solution Approach 1:
The patent embeds the reagent strip storage function within the collection tube structure itself. The reagent strip is positioned inside the collection tube, utilizing the existing internal space rather than requiring a separate external storage container. This nesting approach maintains reagent storage capacity while minimizing overall device volume.
Solution Approach 2:
The reagent strip is designed to be positioned in a specific orientation within the collection tube, utilizing vertical space efficiently. The strip extends along the inner wall of the tube, making use of the cylindrical dimension rather than requiring additional external space, thereby reducing overall device footprint.
3Quantity of substance
If the sample absorbent body is used to hold liquid specimen, then sample collection is achieved, but significant residual liquid remains causing specimen waste
Solution Approach 1:
The piercing component is pre-positioned at the bottom of the collection tube, ready to puncture the sealing membrane before the lysis solution is added. This preliminary positioning ensures that the specimen can be efficiently mixed and transferred without residual waste, as the mixing action occurs before any potential loss points.
Solution Approach 2:
The collection tube structure itself facilitates complete specimen utilization through its integrated design. The tapered bottom and positioning features guide the specimen and lysis solution mixture toward the detection area, enabling the system to self-drain and minimize residual liquid without requiring additional external components or manual intervention.
Data Source
AI summary
The disclosure discloses a liquid specimen lysis detection device. The device includes a detection unit, a lysis unit and a detachable limit structure, where the detection unit includes a detection shell, a sample acquisition unit and a detection reagent strip, the lysis unit includes a base, a piercing sleeve, a sealing film and a bottom bottle. The detachable limit structure is installed between the detection unit and the lysis unit to limit the depth of the detection unit inserted into the top opening of the base in the initial state, so as to prevent the piercing sleeve from piercing the sealing film. In the detection state, the detachable limit structure is removed, and the piercing sleeve pierces the sealing film under the push of the plug-in section of the detection shell; the sample acquisition unit extends into the bottom bottle.