Portable Sensor System for Early Inter-Vascular Occlusion Detection
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Solution Overview
Problem
Current methods for diagnosing and treating ischemic strokes caused by large vessel occlusions are hindered by the time it takes to reach a hospital equipped with necessary facilities and trained professionals, often resulting in delayed administration of effective treatments like IV tPA and mechanical thrombectomy.
Innovation Solution
A system and method using sensors to detect inter-vascular occlusions by comparing blood flow indications from both hemispheres of the brain, allowing for early detection and rapid intervention, potentially even at the patient's location or in an ambulance, using sensors such as piezoelectric devices or ultrasound transducers to determine occlusions based on pressure waveforms, blood flow rates, and vascular impedance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If professional clinical diagnosis and CTA are performed at a hospital, then diagnostic accuracy is improved, but time to diagnosis is increased
Solution Approach 1:
The portable device performs preliminary detection of large vessel occlusion using pressure waveform analysis at the patient's location or in an ambulance, enabling early identification of stroke candidates before hospital arrival. This preliminary action allows for immediate treatment decisions without waiting for hospital-based CTA, thus reducing time to diagnosis while maintaining sufficient accuracy for emergency intervention
Solution Approach 2:
The invention extracts the essential diagnostic function from the hospital-based CTA system by implementing a portable device that uses pressure waveform analysis to detect LVO. This extracted function can operate independently at the point of care, eliminating the need for immediate hospital evacuation for initial diagnosis, thereby reducing diagnostic time while preserving the core diagnostic capability
2Reliability
If patient is evacuated to a hospital with CTA and MT unit, then treatment capability is improved, but time to treatment is increased
Solution Approach 1:
The portable device enables preliminary detection and confirmation of LVO at the patient's location or in the ambulance, allowing treatment decisions to be made before hospital arrival. This preliminary action reduces the time to treatment by eliminating the delay associated with hospital evacuation and CTA scheduling, while the extracted and transferred patient ensures access to advanced treatment capabilities at the hospital
3Loss of time
If portable detection device is used, then time to detection is reduced, but measurement precision may be compromised
Solution Approach 1:
The invention replaces the complex mechanical CTA imaging system with a simpler pressure waveform analysis system that uses piezoelectric sensors to detect occlusion events. This substitution maintains sufficient detection accuracy for emergency LVO identification while enabling portable operation and immediate detection, thus reducing time to detection without sacrificing the essential diagnostic accuracy needed for emergency intervention
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables early detection of large vessel occlusions, reducing the time to medical treatment and potentially improving clinical outcomes by allowing for timely administration of treatments like IV tPA or mechanical thrombectomy.
Implementation Method 1
the first and second indications may include a first pressure waveform and a second pressure waveform
Implementation Method 2
the first and second indications may include a first blood flow rate and a second blood flow rate
Implementation Method 3
the first and second indication are measurements of a first vascular impedance of the first artery and a second vascular impedance of the second artery
Implementation Method 4
determining the occurrence of the inter-vascular occlusion may include detecting a pressure hammer waves in one of the first artery and the second artery
Data Source
AI summary
Some aspects of the invention may be directed to a system and method of determining an occurrence of inter-vascular occlusion. The method may include: receiving, from a first sensor, a first indication, related to blood flow in a first artery supplying blood to a first hemisphere of a subject's brain; receiving from one of: the first sensor and a second sensor, a second indication related to the blood flow in a second artery supplying blood to a second hemisphere of the subject's brain; comparing the first and second indications; and determining an occurrence of an inter-vascular occlusion based on the comparison.