Interatrial Septum Tissue Analysis for Cardiac Amyloidosis Diagnosis
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Solution Overview
Problem
Current methods for diagnosing and treating heart disease, particularly cardiac amyloidosis, are inefficient and require separate procedures for biopsy, leading to potential complications and prolonged recovery times.
Innovation Solution
The development of devices and systems that enable the formation of an anastomosis between the right and left atria, allowing for the removal and analysis of interatrial septum tissue to diagnose cardiac amyloidosis while simultaneously reducing left atrial blood pressure, thereby integrating diagnosis and treatment into a single procedure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If separate biopsy procedures are performed for diagnosing cardiac amyloidosis, then diagnostic accuracy is improved, but procedural complexity and recovery time increase
Solution Approach 1:
The patent combines the diagnostic biopsy procedure with the therapeutic anastomosis procedure into a single integrated intervention. The biopsy forceps are used to both obtain tissue samples for diagnosis and create the anastomosis opening between atria, eliminating the need for separate procedures and reducing overall procedural complexity while maintaining diagnostic accuracy
Solution Approach 2:
The biopsy forceps device is designed to perform multiple functions: obtaining tissue samples for diagnosis and creating the anastomosis opening. This multi-functional approach allows a single device to address both diagnostic and therapeutic needs, reducing the number of devices and procedures required
2Reliability
If multiple separate procedures are performed for diagnosis and treatment, then treatment effectiveness is improved, but treatment time and patient recovery period increase
Solution Approach 1:
The patent merges diagnostic biopsy and therapeutic anastomosis into a single procedure performed through the same access point using the same device. This integration reduces the total treatment time and number of recovery periods while maintaining both diagnostic accuracy and therapeutic effectiveness for cardiac amyloidosis management
Solution Approach 2:
The biopsy is performed first during the same procedure to establish diagnosis before proceeding with the anastomosis treatment. This preliminary diagnostic action ensures that treatment effectiveness can be targeted appropriately while maintaining the efficiency of a single integrated procedure
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for a more accurate and efficient diagnosis of heart conditions like cardiac amyloidosis, reducing the number of steps and improving patient outcomes by enabling both diagnosis and treatment through a single anastomosis procedure, thereby enhancing procedural efficiency and safety.
Implementation Method 1
tissue ablation may comprise delivering a biphasic radiofrequency waveform to the interatrial septum
Data Source
AI summary
Disclosed herein are methods, systems, and devices for diagnosing and treating heart failure. In some variations, a method of treating a patient may comprise forming an anastomosis between a right atrium and a left atrium of the patient by removing a portion of an interatrial septum. The removed portion of the interatrial septum may be analyzed for a cardiac amyloidosis diagnosis.