Interatrial Shunt Conduit With Discrete Frames for Thrombosis Resistance
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Solution Overview
Problem
Existing treatments for heart failure, such as heart diseases and hypertension, lack adaptable methods and devices that effectively manage blood pressure between heart chambers and reduce thrombosis risk.
Innovation Solution
An implantable medical device with discrete frame components and a conduit portion, featuring a membrane unsupported by the frame components, allows for customizable deployment and fluid flow management, reducing thrombosis risk and enhancing therapeutic efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If a continuous frame structure is used to support the conduit, then structural strength is improved, but thrombosis risk increases due to frame components within the conduit lumen
Solution Approach 1:
The frame is divided into discrete separate components (first frame component and second frame component) positioned at opposite ends of the conduit portion, with no frame components within the conduit lumen. This segmentation maintains structural strength while eliminating thrombosis risk by removing continuous frame support from the fluid flow path.
Solution Approach 2:
Frame components are extracted from the conduit portion entirely, with the conduit being free of frame components within its length. The frame components are positioned only at the ends, connecting to the membrane but not extending into the conduit lumen, thereby removing the source of thrombosis risk while preserving structural integrity through end-support mechanisms.
2Stability of the object's composition
If the conduit portion is fully supported by frame components, then structural stability is improved, but adaptability to different anatomies is reduced
Solution Approach 1:
The frame is segmented into discrete components at the ends of the conduit, allowing the membrane to conform to varying anatomical shapes while the end frame components provide stable anchoring points. This segmentation enables adaptation to different anatomies without compromising structural stability.
Solution Approach 2:
The membrane is made radially unsupported and flexible, allowing it to dynamically adapt to different anatomical configurations while the discrete frame components at the ends provide stable anchoring. This dynamic membrane can conform to various shapes while maintaining structural integrity through its boundary conditions.
3Ease of operation
If frame components are placed within the conduit portion, then deployment control is improved, but endothelization is inhibited due to frame presence
Solution Approach 1:
The frame is segmented into discrete components positioned only at the ends of the conduit, allowing deployment control to be exercised through the frame components and delivery system while the conduit portion remains free of frame components. This enables full endothelization of the conduit surface without compromising deployment control.
Solution Approach 2:
Frame components are extracted from the conduit portion, removing obstacles to endothelization. The conduit is made free of frame components within its length, allowing complete endothelial cell coverage while deployment control is maintained through the end frame components and delivery catheter system.
Data Source
AI summary
An implantable medical device comprising a first frame component. The first frame component including a first set of elongate elements configured to conform to an anatomy of a patient. The implantable medical device also comprising a second frame component including a second set of elongate elements configured to conform to an anatomy of a patient. The first frame component and the second frame component being discrete and separate from one another. The implantable medical device also comprising a conduit portion arranged between the first frame component and the second frame component. The conduit portion including a membrane connecting the first frame component and the second frame component.