Interface-Media Dialysis Device for Viscous Biological Fluid Flow

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Solution Overview

Problem

Conventional dialyzers and dialysis systems are unsuitable for biological dialysis fluid due to issues such as viscosity resistance, clotting, blocked flow paths, asymmetrical membrane structures, and safety risks, particularly when using blood-like fluids.

Innovation Solution

A dialysis device with separate chambers for patient blood, biological dialysis fluid, and interface media (e.g., electrolyte solution) allows indirect communication via a third fluid, using membranes like hollow fibers or flat membranes, with safety detectors and circulation systems to manage fluid flow and prevent direct contact.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Area of stationary object

If conventional dialyzer with hollow fibers is used, then membrane area is increased for dialysis, but flow resistance increases and treatment efficiency is compromised due to viscosity of biological dialysis fluid

Engineering Contradiction:
Improvemembrane areaVSAvoidtreatment efficiency
Core Design Contradiction:
Area of stationary objectVSProductivity

Solution Approach 1:

The dialyzer is divided into multiple flow channels instead of using a single large hollow fiber bundle. This segmentation reduces flow resistance in each channel while maintaining total membrane area, allowing biological dialysis fluid to flow more efficiently through the system without compromising treatment effectiveness

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The invention uses symmetrical membrane structure with equal flow distribution, contrasting the asymmetrical structure of conventional dialyzers. This symmetrical design ensures uniform flow velocity across all channels, preventing stagnant areas and reducing clotting risk while maintaining adequate membrane surface area for dialysis

Inventive Principle:
Principle #4Asymmetry

2Duration of action of moving object

If biological dialysis fluid is used to replace conventional dialysis fluid, then treatment can be continuous with recycling, but clotting risk increases in stagnant and congested areas

Engineering Contradiction:
Improvecontinuous treatment capabilityVSAvoidclotting resistance
Core Design Contradiction:
Duration of action of moving objectVSReliability

Solution Approach 1:

The dialyzer design incorporates dynamic flow distribution that ensures continuous movement of biological dialysis fluid through all channels. The symmetrical multi-channel structure prevents stagnant areas where clotting could occur, enabling reliable continuous treatment with fluid recycling

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The design inherently provides flow feedback through its symmetrical structure where flow rate and pressure are evenly distributed across all channels. This balanced flow pattern prevents localized congestion that would lead to clotting, ensuring reliable operation during continuous treatment

Inventive Principle:
Principle #23Feedback

3Ease of operation

If conventional dialyzer structure is used with biological dialysis fluid, then dialysis function is provided, but safety risk increases due to undetectable membrane rupture when blood components are present

Engineering Contradiction:
Improvedialysis functionVSAvoidsafety risk from membrane rupture
Core Design Contradiction:
Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The invention introduces an intermediary detection system using the third chamber and interface media to monitor the dialysis process. This intermediary layer allows for detection of membrane integrity issues through flow pattern analysis and pressure monitoring, providing early warning of potential membrane rupture before it affects patient safety

Inventive Principle:
Principle #24Intermediary (Mediator)

4Productivity

If asymmetrical membrane structure is used, then conventional dialysis fluid flow is optimized, but flow distribution becomes uneven for blood-like fluid causing stagnant areas

Engineering Contradiction:
Improveconventional dialysis fluid flow efficiencyVSAvoidflow distribution uniformity
Core Design Contradiction:
ProductivityVSStability of the object's composition

Solution Approach 1:

The invention deliberately uses symmetrical membrane structure with equal flow distribution characteristics, contrasting the asymmetrical structure of conventional dialyzers. This symmetrical design ensures uniform flow velocity across all channels for viscous biological dialysis fluid, eliminating stagnant areas and preventing clotting while maintaining adequate dialysis function

Inventive Principle:
Principle #4Asymmetry

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Ensures efficient and safe dialysis treatment by minimizing stagnant flow, optimizing fluid volume, and preventing direct contact between patient and biological dialysis fluid, enhancing treatment efficiency and safety.

Implementation Method 1

the first fluid flowing through the first membrane can be indirectly communicated with the second fluid flowing through the second membrane via the third fluid

Methodology Applied
Scientific EffectIndirect fluid communication via interface media:

Implementation Method 2

a first membrane and a second membrane, wherein a first chamber formed by the first membrane is configured to receive a first fluid; a second chamber formed by the second membrane is configured to receive a second fluid; a third chamber formed in between a housing, the first membrane and the second membrane is configured to receive a third fluid

Methodology Applied
Scientific EffectMembrane separation: Semipermeable Membrane

Data Source

PatentUS12403229B2Dialysis device for use with interface media, dialysis systems, use of dialysis device, method for establishing dialysis system, method for filling and/or priming dialysis system and method for removing air from dialysis system
Publication Date: 2025.09.02 FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
  • US12403229B2 patent drawing
  • US12403229B2 patent drawing
  • US12403229B2 patent drawing

AI summary

A dialysis device comprises at least a first membrane and a second membrane, wherein a first chamber formed by the first membrane is configured to receive a first fluid; a second chamber formed by the second membrane is configured to receive a second fluid; a third chamber formed in between a housing, the first membrane and the second membrane is configured to receive a third fluid; the first fluid flowing through the first membrane can be indirectly communicated with the second fluid flowing through the second membrane via the third fluid. A dialysis system, use of the dialysis device, a method for establishing the dialysis system, a method for filling and/or priming the dialysis system and a method for removing air are further disclosed. The dialysis device and the dialysis system are suitable for viscous biological dialysis fluid and no direct flow occurs between the patient and the dialysis fluid.