Interpenetrating Microstructures for Deep-Tissue Sampling and Delivery
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Solution Overview
Problem
Current nanochannel-based delivery methods are limited to delivering cargo only to the outermost cell layer of a tissue, restricting their action range and effectiveness.
Innovation Solution
Development of microstructure arrays with nanochannels that penetrate deeper into tissues, featuring multiple channels at different heights and angles to deliver cargo to various cell layers, combined with a frame that can be applied to curved surfaces and using electroporation for controlled delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nanochannel-based delivery methods are used, then cargo delivery capability is improved, but delivery depth is limited to outermost cell layer
Solution Approach 1:
The patent transitions from a single-layer delivery system to a multi-layer delivery system by creating microstructures with channels at different heights and depths. The microstructures include a first channel extending to a first depth and a second channel extending to a second depth greater than the first depth, enabling cargo delivery to multiple cell layers simultaneously. This dimensional expansion in the depth dimension resolves the contradiction between maintaining reliable delivery capability and increasing delivery depth.
2Adaptability or versatility
If multiple channels at different heights are used, then delivery range to multiple cell layers is improved, but device complexity increases
Solution Approach 1:
The patent divides the delivery device into multiple segmented microstructures, where each microstructure contains channels at different depths. Each microstructure can be independently configured with specific channel depths and orientations to target different cell layers. This segmentation allows the complex multi-layer delivery function to be broken down into manageable, repeating units, reducing overall device complexity while maintaining versatility.
Solution Approach 2:
The patent implements a nested channel structure where multiple channels are embedded within each microstructure body. The channels are nested at different depths and orientations within the same microstructure, allowing multiple delivery functions to be integrated into a single compact unit. This nesting approach reduces device complexity by consolidating multiple delivery pathways into unified microstructure elements rather than requiring separate structures for each channel.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables targeted and controlled delivery of substances to multiple layers of biological tissues, enhancing the effectiveness and range of nanochannel-based cargo delivery systems.
Implementation Method 1
combined with a frame that can be applied to curved surfaces and using electroporation for controlled delivery
Data Source
AI summary
Provided herein are devices and methods for topically and controllably delivering cargo or collecting samples into or from biological tissues, particularly the skin. These devices permit delivery of cargo and collection of samples from cell layers deep within a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.