Interstitial Fluid Pressure Sensor for Heart Failure Monitoring
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Solution Overview
Problem
Current methods for managing conditions like heart failure, sepsis, and chronic kidney disease face challenges in accurately assessing and addressing fluid overload, particularly in the interstitial space, leading to inadequate treatment and increased mortality.
Innovation Solution
A device and method for measuring subcutaneous interstitial pressure (SCIP) or total tissue pressure (TTP) to monitor and adjust therapies, using a perforated capsule with a pressure sensor and amplifier to provide non-invasive, continuous data on interstitial fluid accumulation and pressure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional methods (clinical assessment, bioimpedance, ultrasound) are used to assess fluid overload, then the assessment is non-invasive and easy to perform, but the measurement precision and reliability are insufficient
Solution Approach 1:
The patent introduces an interstitial fluid pressure sensor as an intermediary device that directly measures pressure in the interstitial space, providing accurate fluid overload assessment without requiring complex imaging or electrical impedance calculations. The sensor acts as a mediator between the physiological state and the measurement system.
Solution Approach 2:
The patent replaces complex mechanical and electrical assessment systems (ultrasound imaging, bioimpedance analysis) with a simple pressure sensing mechanism that directly measures interstitial fluid pressure, thereby improving measurement precision while reducing device complexity.
2Reliability
If interstitial fluid pressure monitoring is implemented, then treatment guidance becomes more precise and timely, but the device complexity and invasiveness increase
Solution Approach 1:
The patent implements preliminary action by placing the interstitial fluid pressure sensor before clinical decompensation occurs, allowing continuous monitoring and early intervention. The sensor is positioned in advance to capture pressure changes as they occur, enabling proactive treatment adjustment.
Solution Approach 2:
The patent establishes a feedback loop where interstitial fluid pressure measurements continuously inform treatment decisions. The pressure data feeds back to clinicians in real-time, allowing dynamic adjustment of diuretic therapy and other interventions based on actual physiological status rather than periodic assessments.
3Loss of information
If current fluid management approaches are used, then treatment is simpler to administer, but the loss of information about actual fluid status leads to inadequate treatment and increased mortality
Solution Approach 1:
The patent implements continuous feedback through interstitial pressure monitoring, eliminating information loss about actual fluid status. The pressure measurements provide real-time data that prevents mismanagement, allowing clinicians to respond appropriately to changing fluid conditions without delay or uncertainty.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise monitoring and intervention in fluid overload conditions, potentially reducing hospitalizations and mortality by providing real-time data on interstitial fluid status, guiding diuretic therapy, fluid resuscitation, and optimizing treatment in heart failure and sepsis, and aiding in dry weight determination in kidney disease.
Implementation Method 1
measuring subcutaneous interstitial pressure (SCIP) or total tissue pressure (TTP)
Data Source
AI summary
Method and devices for treating a physiologic condition of a patient using measurements of pressure of an interstitial space of a patient as an indicator of required therapy.