Intervertebral Disc Regeneration Using Human Birth Tissue
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Solution Overview
Problem
Current treatments for degenerative disc disease, such as discectomy and spinal fusion, do not address the underlying biological issue and often lead to complications like adjacent segment disease, necessitating a more effective and safer method for treating the condition.
Innovation Solution
Administration of a human birth tissue material composition, including components like placental tissue, umbilical cord blood, and amniotic membrane, into or onto intervertebral discs to regenerate disc-like tissue and alleviate degenerative disc disease symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If discectomy is performed to relieve pain from neural compression, then pain relief is achieved, but the underlying biological problem is not treated and adjacent segment disease may develop
Solution Approach 1:
The patent extracts and removes the degraded nucleus pulposis tissue from the intervertebral disc, then replaces it with allogeneic nucleus pulposis tissue. This extraction approach addresses both the immediate pain relief need and the long-term biological health of the disc by removing harmful degraded material and replacing it with functional tissue.
Solution Approach 2:
The patent changes the biological parameters of the intervertebral disc by introducing living allogeneic nucleus pulposis cells that can regenerate extracellular matrix and maintain disc hydration. This transforms the disc from a degenerating structure to one with active regenerative capacity, improving long-term reliability.
2Stability of the object's composition
If spinal fusion is performed to immobilize affected vertebrae, then stability is improved, but adjacent segment disease is limited and the duration of success is reduced
Solution Approach 1:
The patent enables the intervertebral disc to serve itself by introducing allogeneic nucleus pulposis cells that autonomously regenerate extracellular matrix, produce proteoglycans, and maintain disc hydration. This self-service regenerative capability provides long-term stability without requiring external fusion hardware or sacrificing adjacent segment mobility.
3Reliability
If autologous tissue is used for grafting, then biocompatibility is improved, but graft site morbidity occurs
Solution Approach 1:
The patent uses allogeneic nucleus pulposis tissue as an intermediary that provides the beneficial biological functions of autologous tissue without requiring harvesting from the patient's own body. The allogeneic tissue serves as a mediator that delivers regenerative capabilities while avoiding the morbidity associated with autologous tissue harvesting sites.
Data Source
AI summary
Methods for treating degenerative disc disease by administering a human birth tissue material composition are provided. The method includes the step of administering a human birth tissue material composition onto or into at least one intervertebral disc or intervertebral space in need of treatment.