Interwoven Fluid Manifold Assembly for Aseptic Transfer Validation
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Solution Overview
Problem
Biopharmaceutical and vaccine manufacturing processes face challenges in fluid transfer and distribution due to the complexity and error-prone assembly of disposable fluidic conduits, which can lead to operational inefficiencies and aseptic assurance issues.
Innovation Solution
A structured assembly of interwoven fluid conduits with a multiport valve head and adjustable connections, allowing for flexible and scalable fluid transport and distribution systems that can be easily validated and automated, featuring permanent or adjustable check valves and programmable circuitry for user-controlled fluid flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If disposable fluidic conduits are used for fluid transfer, then aseptic assurance is improved and chemical waste for cleaning is reduced, but assembly complexity increases and operator errors increase
Solution Approach 1:
The patent combines multiple fluid conduits into a single integrated manifold structure with pre-configured connection points. The manifold integrates multiple input conduits, output conduits, and internal fluid distribution pathways into one unified component, eliminating the need for operators to assemble multiple separate conduits and reducing assembly complexity while maintaining aseptic assurance.
Solution Approach 2:
The manifold is pre-configured with predetermined connection points and internal fluid pathways during manufacturing. This preliminary arrangement of fluid routes and connection geometry eliminates the need for complex on-site assembly operations, reducing operator errors while preserving the aseptic benefits of disposable conduits.
2Adaptability or versatility
If multiple separate fluid conduits are assembled to achieve fluid distribution, then fluid transport flexibility is improved, but assembly time increases and operator errors increase
Solution Approach 1:
The manifold integrates multiple fluid distribution functions into a single component with pre-configured connection points for multiple conduits. This merging of functions allows flexible fluid transport configurations to be achieved through simple connection operations rather than complex assembly procedures, reducing assembly time while maintaining transport flexibility.
Solution Approach 2:
The manifold serves multiple fluid distribution functions simultaneously through its integrated structure with multiple input and output conduits. This multi-functional design enables a single component to handle various fluid transport configurations, reducing the number of separate components needed and thereby reducing assembly time while preserving flexibility.
3Adaptability or versatility
If complex fluid transfer systems are assembled from basic components, then system versatility is improved, but validation difficulty increases
Solution Approach 1:
The manifold combines multiple fluid pathways and connection points into a single integrated component with known and controlled internal geometry. This integration simplifies validation by providing a unified structure with predictable fluid distribution characteristics, making it easier to detect and measure system performance while maintaining the versatility of multiple fluid handling capabilities.
4Adaptability or versatility
If manual assembly of fluid conduits is performed, then system customization is improved, but productivity decreases
Solution Approach 1:
The manifold integrates multiple fluid distribution functions into a single pre-configured component that can be quickly installed as one unit. This integration maintains system customization capabilities while dramatically improving productivity by reducing the number of assembly operations required, allowing faster deployment of customized fluid distribution systems.
Data Source
AI summary
A structured assembly of perpendicular, interwoven fluidic conduits permits connections between conduits to be readily (and in some cases visibly) established, thereby providing operational convenience and amenability to automated means of validation or verification.