Intra-canal Composition for Root Canal Disinfection
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Solution Overview
Problem
Current endodontic treatments lack a single medicament effective against Enterococcus faecalis, Candida albicans, and Streptococcus mutans, which are prevalent in root canal infections, and existing irrigants fail to eradicate these microorganisms completely due to limitations such as requiring direct contact, inactivation inefficiencies, and tissue irritation.
Innovation Solution
A composition containing calcium hydroxide, sodium hydroxide, potassium thioglycolate, and other agents that break disulfide bonds in tissues and microorganisms, providing a single intra-canal medicament capable of dissolving tissues, removing debris, disinfecting, and eradicating bacteria and fungi, including those in biofilms, while lubricating and preparing surfaces for stem cell therapy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple separate medicaments are used to target different microorganisms, then the effectiveness against various bacteria and fungi improves, but the treatment complexity and number of steps increase
Solution Approach 1:
The patent combines multiple medicaments with different mechanisms of action into a single composition. The composition includes a first medicament effective against Enterococcus faecalis and a second medicament effective against Candida albicans and Streptococcus mutans, merging them into one formulation that can be applied simultaneously to address multiple pathogens without requiring separate treatment steps
Solution Approach 2:
The single composition is designed to be universally effective against multiple types of microorganisms including bacteria and fungi. The medicaments work synergistically to provide broad-spectrum coverage, making the composition adaptable to various endodontic infection scenarios without requiring different formulations for different pathogens
2Ease of operation
If existing irrigants are used to remove tissue and debris, then the cleaning effect improves, but the ability to eradicate microorganisms completely deteriorates
Solution Approach 1:
The composition merges the functions of tissue dissolution, debris removal, and microorganism eradication into a single formulation. The medicaments are selected to work synergistically, providing both mechanical cleaning through tissue dissolution and chemical eradication of microorganisms, eliminating the need for separate cleaning and disinfection steps
3Reliability
If strong bactericidal agents are used to eradicate microorganisms, then the disinfection effectiveness improves, but tissue irritation and harmful effects increase
Solution Approach 1:
The patent carefully selects and adjusts the concentrations and properties of the medicaments to optimize the balance between disinfection effectiveness and tissue safety. By changing the parameters of the medicaments (such as concentration, pH, and chemical structure), the composition achieves potent microorganism eradication while minimizing harmful effects on surrounding tissues
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces microorganism counts by 99% or more, facilitating complete removal of infected tissue and debris, reducing the risk of apical periodontitis and bacteremia, and enabling successful root canal treatments with minimal patient discomfort and quick application time.
Implementation Method 1
A composition containing calcium hydroxide, sodium hydroxide, potassium thioglycolate, and other agents that break disulfide bonds in tissues and microorganisms
Implementation Method 2
providing a single intra-canal medicament capable of dissolving tissues, removing debris, disinfecting
Data Source
AI summary
A single intra-canal substance composition for tissue dissolution, disinfection, tissue degradation, tissue removal and disinfection is provided. The composition includes calcium hydroxide, sodium hydroxide, potassium thioglycolate or calcium thioglycolate, to form an effective single intra-canal substance capable of degrading a cell by disrupting its disulfide bonds. Further, the composition may incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, water fragrance, lanolin, and ceteareth-20 to enhance its functioning. Furthermore, the composition that is bactericidal against Enterococcus faecalis, Streptococcus mutans and Candida albicans, used in multiple applications in dentistry and medicine. Furthermore, the composition is a single intra-canal irrigant that eradicates microorganisms as it facilitates the chemo-mechanical debridement of the root canal system.