Intracranial Drug Injection Apparatus with Modular Guide and Tube
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Solution Overview
Problem
Current methods for administering stem cells into the brain for treating Alzheimer's dementia face challenges such as difficulty in passing through the blood-brain barrier and inaccuracy of delivery, leading to cumbersome and painful procedures with existing devices.
Innovation Solution
An apparatus and method for intracranial drug injection involving a body unit with a through-hole, a cap unit, and a tube unit that allows for precise and repeated administration of stem cells or brain disease treatment drugs directly to affected brain lesions without skin incision, utilizing a funnel-shaped first through unit and a tapered tube unit for accurate delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a delivery device with a bent guide is used for administration of stem cells, then the stem cells can be administered into the brain, but the accuracy of the procedure is reduced because the guide is bent
Solution Approach 1:
The delivery device is divided into separate modular components including a guide portion and an injection portion that can be assembled and disassembled. This segmentation allows the guide to maintain its shape during storage and transport, and enables replacement of the guide if bending occurs, thereby maintaining procedural accuracy across multiple administrations.
Solution Approach 2:
The device is designed with pre-formed guides that are straight and rigid before use. The guide portion is prepared in advance with the correct geometry and stiffness characteristics, and is attached to the injection portion just before the procedure. This preliminary preparation ensures the guide maintains its intended shape and provides accurate positioning for stem cell administration.
2Duration of action of moving object
If repeated administration procedures are performed using the same delivery device, then multiple doses can be administered, but the procedure becomes cumbersome and time-consuming
Solution Approach 1:
The delivery device is designed with separable components that can be quickly assembled and disassembled. The injection portion can be removed and replaced with a new sterile injection component between administrations, while the guide portion remains in place. This segmentation enables rapid repeated administrations without requiring complete device replacement or complex repositioning procedures.
Solution Approach 2:
The device allows for disposal of single-use sterile components (such as injection portions or seals) while retaining and reusing the non-sterile guide portion. After each administration, the used injection component is discarded and a new one is attached to the guide, enabling repeated procedures without the time and cost of complete device replacement while maintaining sterility requirements.
3Quantity of substance
If traditional surgical procedures are used for stem cell administration, then drugs can be delivered to the brain, but the procedure is painful and requires skin incision
Solution Approach 1:
The injection portion of the device is designed to be inserted through a small puncture in the scalp rather than requiring a large surgical incision. The guide portion can be inserted through this minimal opening and positioned in the brain, and the injection portion is attached externally. This extraction of the injection function from traditional surgical approaches allows drug delivery with minimal patient trauma and pain.
Solution Approach 2:
The delivery device acts as an intermediary structure that bridges the external injection site and the internal brain target. The guide portion extends through the skull and brain tissue to reach the target location, while the injection portion remains external and connects to the guide. This intermediary structure enables drug delivery without requiring direct surgical access to the brain, reducing patient pain and trauma.
Data Source
AI summary
The present disclosure provides an apparatus for intracranial drug injection including a body unit having a through-hole extending between a first opening in a topmost surface and a second opening in a bottommost surface, a cap unit having a shape corresponding to at least a part of an inner surface of the through-hole and being inserted into the first opening to cover the first opening, and a tube unit having one end coupled to the second opening and another end extending toward an affected brain lesion.