Intracranial Volume Adaptor Synchronization Cardiac Cycle
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Solution Overview
Problem
Current methods for influencing cerebral perfusion are inadequate in effectively synchronizing intracranial pressure modifications with the cardiac cycle to enhance cerebral blood flow, often leading to suboptimal cerebral perfusion pressure and flow rates.
Innovation Solution
A method and system that periodically change the volume of a volume adaptor introduced into the cranial volume, synchronizing these changes with the cardiac cycle to modulate intracranial pressure, involving shrinking and expanding the volume in synchronization with cerebral blood inflow and outflow phases to enhance perfusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If intracranial pressure is modified to enhance cerebral blood flow, then cerebral perfusion is improved, but the synchronization with cardiac cycle phases becomes complex
Solution Approach 1:
The system employs periodic volume changes of the intracranial adaptor synchronized with cardiac cycle phases. The adaptor volume is increased during diastole and decreased during systole, creating periodic pressure modifications that enhance cerebral blood flow while maintaining synchronization with natural cardiac rhythm.
Solution Approach 2:
The system uses feedback from intracranial pressure sensors and cardiac cycle detection to dynamically adjust the adaptor volume changes. The controller receives real-time data on pressure variations and cardiac phases, then modulates the adaptor volume accordingly to optimize synchronization and enhance cerebral perfusion.
2Productivity
If the volume adaptor is changed rapidly to modulate pressure, then cerebral perfusion pressure is enhanced, but intracranial pressure stability deteriorates
Solution Approach 1:
The system uses periodic, rhythmic volume changes synchronized with cardiac cycle phases rather than continuous or rapid changes. The adaptor volume is increased during diastole and decreased during systole, creating controlled periodic pressure modifications that enhance cerebral blood flow while maintaining intracranial pressure stability through physiological synchronization.
Solution Approach 2:
The system dynamically adjusts the adaptor volume parameter in a controlled manner, changing volume from a first value to a second value based on cardiac phase detection. This parameter modulation creates pressure variations that improve cerebral perfusion while maintaining stability through physiologically-appropriate timing and magnitude control.
3Productivity
If continuous volume modification is applied, then cerebral blood flow is maximized, but energy consumption increases
Solution Approach 1:
The system employs periodic volume changes synchronized with cardiac cycle phases rather than continuous modification. The adaptor volume is adjusted during specific phases (increased during diastole, decreased during systole), creating energy-efficient periodic pressure modifications that enhance cerebral blood flow without requiring continuous energy input.
Solution Approach 2:
The system leverages the natural cardiac cycle to drive the volume modifications, using the heart's own rhythmic contraction and relaxation to timing the adaptor volume changes. This self-synchronized approach eliminates the need for external energy input to maintain rhythm, reducing overall energy consumption while maximizing cerebral blood flow enhancement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly improves cerebral perfusion by optimizing intracranial pressure changes during the cardiac cycle, leading to enhanced cerebral blood flow and volume, addressing the limitations of existing techniques.
Implementation Method 1
modifying a volume of a volume adaptor introduced into a cranial volume of a patient... shrinking a volume of the volume adaptor to a decreased volume state in synchronization to an estimated timing of a cerebral blood inflow, to an amount sufficient to decrease an intracranial pressure in the cranial volume... increasing a volume of the volume adaptor to an increased volume state
Data Source
AI summary
A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.