Intraluminal GI Photobiomodulation With Reflectance Feedback

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Solution Overview

Problem

Traditional photobiomodulation (PBM) methods are ineffective for treating internal areas of the body, particularly the gastrointestinal (GI) tract, due to limited light penetration depth, and existing delivery schemes are costly and invasive.

Innovation Solution

A system and method for therapeutic gastrointestinal PBM using an intraluminal device with light delivery and detection components, coupled with a signal processor and wireless transceiver, allowing for real-time adjustment of light therapy based on reflectance measurements to enhance penetration and minimize invasiveness.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If traditional PBM is applied through the skin, then the treatment is non-invasive and safe, but the light penetration depth is limited and cannot reach internal areas like the GI tract

Engineering Contradiction:
Improvelight penetration depth limitationVSAvoidinvasiveness of delivery method
Core Design Contradiction:
Object-affected harmful factorsVSEase of operation

Solution Approach 1:

Instead of delivering light from outside the body through the skin (traditional approach), the patent inverts the delivery approach by placing light sources inside the GI tract. The system uses intraluminal devices that are swallowed or inserted into the GI tract, allowing light to be delivered directly to the target tissue from within the lumen, thereby overcoming the penetration depth limitation without requiring invasive surgical procedures.

Inventive Principle:
Principle #13The other way round (Inversion)

Solution Approach 2:

The patent introduces an intermediary delivery system - intraluminal devices containing light sources that travel through the GI tract. These devices serve as mediators between the external light source and the internal GI tract tissue, enabling deep tissue penetration while maintaining a non-invasive external interface. The devices can be swallowed capsules or inserted through the mouth, avoiding surgical incisions.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Object-affected harmful factors

If existing delivery schemes are used to reach internal areas, then light penetration depth is improved, but the cost and burden on patients increases

Engineering Contradiction:
Improvelight penetration depthVSAvoidcost and burden of delivery system
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The patent employs disposable intraluminal devices that are swallowed or inserted into the GI tract, perform their therapeutic function, and then naturally pass through the digestive system to be expelled. These single-use devices eliminate the need for expensive, complex, reusable systems with sterilization requirements. The devices are designed to be inexpensive enough to be discarded after one use, significantly reducing patient burden and healthcare costs.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The intraluminal devices are designed to be self-contained and self-operating. They contain integrated light sources, control circuits, and power supplies that automatically deliver the prescribed photobiomodulation therapy without requiring external control or monitoring during operation. The devices navigate the GI tract independently and expel themselves naturally, eliminating the need for complex external manipulation equipment and specialized medical personnel intervention.

Inventive Principle:
Principle #25Self-service

3Device complexity

If traditional PBM is used, then the system is simple, but it cannot effectively treat GI tract conditions due to insufficient light penetration

Engineering Contradiction:
Improvesimplicity of systemVSAvoidtherapeutic effectiveness for GI conditions
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

The patent segments the light delivery system into multiple independent intraluminal devices that can be distributed throughout the GI tract. Each device contains its own light sources and control systems, allowing targeted therapy at specific locations (stomach, small intestine, colon) without requiring a single complex system. This segmentation maintains relative simplicity of individual components while achieving reliable overall therapeutic effect through multiple distributed treatment points.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system enables selective biomodulation of GI tissues, reducing cost and burden on patients while effectively treating conditions like peptic ulcers, bowel resection complications, and inflammation by enhancing light penetration and allowing non-invasive, closed-loop therapy.

Implementation Method 1

The term photobiomodulation ('PBM') refers to the use of electromagnetic radiation of light (traditionally with one or more wavelengths in the ultraviolet ('UV'), visible, or infrared ('IR') portions of the spectrum) to modulate a biological process and produce one or more therapeutic effects.

Methodology Applied
Scientific EffectPhotobiomodulation:

Implementation Method 2

determining, by a signal processing device, whether the photobiomodulation therapy is sufficient to treat the portion of the patient's GI tract based on a reflectance signal detected by at least one photodetector

Methodology Applied
Scientific EffectReflectance: Reflection

Data Source

PatentEP4168111B1System for therapeutic gastrointestinal photobiomodulation
Publication Date: 2025.11.05 NICHE BIOMEDICAL INC
  • EP4168111B1 patent drawingFigure 1~2
  • EP4168111B1 patent drawingFigure 3~4
  • EP4168111B1 patent drawingFigure 5~6

AI summary

Photobiomodulation can be used to treat disorders of the gastrointestinal system. The photobiomodulation can be delivered by an intraluminal device (which can be within the gastrointestinal system) that includes at least one light delivery device configured to provide photobiomodulation; at least one photodetector device to measure reflectance based on the photobiomodulation; a processor to receive a reflectance signal from the at least one photodetector device based on the reflectance measured by the at least one photodetector device and process the reflectance signal; and a wireless transceiver coupled to the processor to transmit at least a portion of the processed reflectance signal. The wireless transceiver can communicate with an external device that includes a wireless transceiver to receive the at least the portion of the processed reflectance signal.