Intramarrow Injection Needle for Bone Marrow Targeting
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Solution Overview
Problem
Current intravenous chemotherapy methods for treating bone marrow diseases like leukemia and lymphoma are inefficient, as they deliver chemotherapeutic agents to non-target regions, requiring high doses and causing detrimental side effects due to low delivery to the bone marrow.
Innovation Solution
A novel needle design with a foldable, winged handle and a shorter, sharper tip for direct intramarrow injection into the sternum and pelvic bone, allowing for effective delivery of chemotherapeutic agents directly into the bone marrow, reducing systemic distribution and toxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If intravenous injection is used to deliver chemotherapeutic agents, then the agents can be administered systemically, but the delivery to the target bone marrow is inefficient and causes high systemic toxicity
Solution Approach 1:
The invention extracts the chemotherapeutic agent delivery directly to the target site (bone marrow) by using a needle that penetrates the bone to access the marrow cavity, separating the target delivery from systemic circulation and thereby reducing off-target toxicity
Solution Approach 2:
The bone-penetrating needle serves as an intermediary device that directly connects the chemotherapeutic agent to the bone marrow target, bypassing the vascular system and eliminating the dilution and distribution problems of intravenous administration
2Quantity of substance
If high doses of chemotherapeutic agents are administered intravenously to ensure effective delivery to bone marrow, then the target dose is achieved, but detrimental side effects occur due to distribution to non-target regions
Solution Approach 1:
The invention applies local quality by delivering the chemotherapeutic agent directly to the local target site (bone marrow) through needle penetration, creating a localized high concentration at the target while maintaining low concentration elsewhere, thereby achieving effective local treatment with minimal systemic side effects
3Adaptability or versatility
If conventional aspiration needles are used, then bone marrow can be obtained for diagnostic purposes, but they are insufficient for direct therapeutic injection into the marrow
Solution Approach 1:
The invention applies universality by designing a single needle device that can perform both bone marrow aspiration for diagnostic purposes and direct chemotherapeutic injection for treatment, eliminating the need for separate procedures and devices while reducing overall treatment complexity
Data Source
AI summary
A method and apparatus for injecting supportive and therapeutic agents into bone marrow. During conventional chemotherapy for leukemia, lymphoma, multiple myeloma and other bone related diseases, chemotherapeutic agents are typically injected intravenously. Intravenous injection, however, as a method of chemotherapy, has a number of potential disadvantages. By injecting therapeutic agents directly into the bone marrow using the present method and apparatus, these disadvantages can be avoided. A stronger needle with a shorter and sharper tip, when compared to a conventional intravenous or sternal puncture needle, designed to optimally administer therapeutic agents into bone marrow without causing injury is disclosed. The method includes injecting therapeutic agents into large reservoirs of bone marrow in accessible areas such as ilium and sternum is most likely to have a significant effect in treating bone marrow diseases. The needle may have side holes for wider and more even distribution of therapeutic agents throughout the marrow.