Intranasal Ammonia-Oxidizing Microorganisms for Inflammation Control
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Solution Overview
Problem
Existing treatments for conditions such as allergic rhinitis, neurogenic inflammation, and systemic inflammatory conditions do not effectively utilize ammonia oxidizing microorganisms to restore the nasal microbiome, leading to inadequate relief of symptoms like congestion and inflammation.
Innovation Solution
Administering ammonia oxidizing microorganisms, such as Nitrosomonas eutropha, directly to the nasal cavity through formulations like nasal drops, sprays, or mists, which colonize target tissues and convert ammonia to nitrite, modulating the microbiome and reducing inflammation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments for allergic rhinitis and inflammatory conditions are used, then symptom relief is provided, but the nasal microbiome is not restored and congestion persists
Solution Approach 1:
The patent converts the harmful accumulation of ammonia in the nasal cavity into a beneficial process by introducing ammonia-oxidizing microorganisms. These microorganisms oxidize ammonia to nitrite, which then converts to nitric oxide, a beneficial substance that reduces inflammation and congestion. This transforms the harmful ammonia accumulation into a therapeutic mechanism.
Solution Approach 2:
The ammonia-oxidizing microorganisms utilize the ammonia already present in the nasal cavity environment as their substrate, converting it into nitrite and subsequently nitric oxide. The system uses its own environmental conditions (ammonia presence) to generate the therapeutic effect without requiring external intervention beyond the initial microorganism introduction.
2Reliability
If ammonia oxidizing microorganisms are administered to the nasal cavity, then the microbiome is restored and inflammation is reduced, but the delivery system becomes more complex
Solution Approach 1:
The delivery system is segmented into simple, common formulations (nasal drops, sprays, mists) that can be easily administered. Rather than requiring complex delivery mechanisms, the patent divides the treatment into straightforward application methods that patients can perform at home, reducing the complexity barrier while maintaining effective microorganism delivery to the nasal cavity.
3Productivity
If ammonia oxidizing microorganisms are introduced to convert ammonia to nitrite, then therapeutic effects are achieved, but the conversion rate must be sufficient to be effective
Solution Approach 1:
The patent optimizes parameters such as pH (maintaining 7.0-8.5 to support microorganism activity), temperature (37°C body temperature), and ammonia concentration to maximize the conversion efficiency. By controlling these parameters, the system achieves effective ammonia-to-nitrite conversion with appropriate microorganism dosing, balancing productivity with substance quantity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The direct administration of ammonia oxidizing microorganisms effectively reduces nasal and sinus congestion, neurogenic inflammation, and systemic inflammatory conditions by promoting endothelial function and altering nitrite levels, providing therapeutic benefits for various disorders including headaches and autoimmune diseases.
Implementation Method 1
ammonia oxidizing microorganisms... convert ammonia to nitrite
Data Source
AI summary
Ammonia oxidizing microorganism preparations for delivery to the intranasal system, kits including ammonia oxidizing preparations for delivery to the intranasal system, and devices for administering ammonia oxidizing preparations to the intranasal system are provided. Methods of introducing ammonia oxidizing microorganisms to the intranasal system are provided. Methods of treating disorders, including neurological disorders, nasal or sinus disorders, and inflammatory disorders, with ammonia oxidizing microorganism preparations are provided.