Intranasal Delivery Device Gas-Phase Impermeable Seal
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Solution Overview
Problem
Current intranasal spray devices are limited in delivering larger volumes of medication, are not gas-phase impermeable, leading to contamination and degradation of medication solutions, and are not ergonomically designed for effective administration, especially in emergency situations.
Innovation Solution
An intranasal delivery device with a gas-phase impermeable design, featuring a cylindrical injector barrel with slit openings, a centering guide, and a pliable rubber stopper with seal rings to prevent gas exchange, along with an ergonomic design for stable and efficient delivery of 0.2 mL to 1 mL of medication solution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If current IN spray devices are used to deliver medication solutions, then smaller amounts (0.1 mL or less) can be delivered, but the device is incapable of delivering larger volumes (0.2 mL to 1 mL) required for certain treatments
Solution Approach 1:
The device is divided into distinct functional components: a vial for medication storage, a pliable stopper with seal rings for sealing, a cannula for fluid delivery, and an injector barrel with slit openings for actuation. This segmentation allows each component to be optimized for its specific function while working together to deliver larger medication volumes.
Solution Approach 2:
The vial is nested within the injector barrel, and the pliable stopper is nested within the vial. The cannula passes through the stopper and extends into the vial. This nested configuration allows compact design while accommodating larger medication volumes and maintaining gas-phase impermeability throughout the system.
2Reliability
If current IN delivery devices are used, then medication solution can be delivered, but the device is not gas-phase impermeable, allowing oxygen gas to contact and degrade the medication
Solution Approach 1:
The device creates a gas-phase impermeable environment by using a pliable stopper with multiple seal rings that prevent oxygen and other gases from contacting the medication solution. The slit openings in the injector barrel are designed to maintain this seal while allowing mechanical actuation, effectively creating an inert protective environment around the medication.
Solution Approach 2:
The pliable stopper combines multiple seal rings made of gas-impermeable material to create a composite sealing structure. This composite design provides enhanced gas-phase impermeability compared to single-seal designs, ensuring medication stability while accommodating the mechanical requirements of the delivery system.
3Ease of operation
If current IN spray devices are used, then medication delivery is possible, but the device lacks ergonomic design for effective administration in emergency situations
Solution Approach 1:
The device incorporates dynamic elements including the movable pliable stopper that responds to compression forces, the base that can be compressed to actuate delivery, and the slit openings that flex during operation. This dynamic design allows the device to be easily actuated in emergency situations while maintaining structural integrity and gas-phase impermeability.
Solution Approach 2:
The pliable stopper is made of flexible material that can be compressed and deformed during actuation. The slit openings in the injector barrel provide flexibility while maintaining the gas barrier. This combination of flexible components allows ergonomic operation without compromising the gas-phase impermeable seal.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively seals medication solutions from gases, preventing contamination, and allows for accurate and stable delivery of higher medication volumes, enhancing usability and safety, particularly in emergency situations.
Implementation Method 1
The vial includes a pliable rubber stopper including a plurality of seal rings, each seal ring having a geometry configured to form a gas-phase impermeable seal with an internal surface of the vial
Data Source
AI summary
An IN delivery gas-phase impermeable device for delivery between 0.2 mL and 1.0 mL of a medication solution is disclosed. The device includes an injector barrel including a plurality of slit openings disposed circumferentially along the injector barrel, a center guide positioned lengthwise within the injector barrel, a cannula in fluid communication with the medication solution fixed in position by the center guide, and a vial configured to couple with the injector barrel. The vial includes a pliable rubber stopper with multiple seal rings, each seal ring having a geometry configured to form a gas-phase impermeable seal with an internal surface of the vial. The cannula bisects the pliable rubber stopper. The device includes a base configured to reversibly engage with one or more of the slit openings of the injector barrel during actuation of the device, which may involve compression of the base toward the injector barrel.