Intranasal Light Therapy Device for Self-Administered Brain Stimulation

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Solution Overview

Problem

Current brain stimulation methods, such as ECT, CES, DBS, TLT, and optogenetics, face limitations including invasiveness, side effects, and lack of portability and cost-effectiveness, particularly for transcranial light therapy, which hinders widespread adoption and convenience.

Innovation Solution

The development of an intranasal neurostimulation system using a small, portable light diode apparatus inserted into the nasal cavity, powered by a dry cell battery, which emits targeted light energy of specific wavelengths to stimulate the brain non-invasively, allowing for self-administration and mobility.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If transcranial light therapy is used to stimulate the brain, then therapeutic outcomes can be achieved, but the device is not portable and cannot be self-administered

Engineering Contradiction:
Improveself-administration capabilityVSAvoiddevice portability
Core Design Contradiction:
Ease of operationVSDevice complexity

Solution Approach 1:

The system is divided into separate functional modules: a portable light source unit, a control unit, and a nasal cavity insert. This segmentation allows the light source to be compact and portable while the insert provides the necessary therapeutic function, enabling self-administration without requiring a complex integrated device.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The nasal cavity insert acts as an intermediary that delivers light energy to the brain through the nasal tissues. This intermediary approach allows portable light sources to effectively stimulate the brain without requiring direct skull penetration or complex surgical implants, thus enabling self-administration.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If invasive brain stimulation methods (ECT, DBS) are used, then therapeutic effects are achieved, but there is brain damage and cognitive deficits

Engineering Contradiction:
Improvetherapeutic effectivenessVSAvoidbrain damage and cognitive deficits
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The invention replaces invasive mechanical/electrical stimulation systems (ECT, DBS) with an optical system. Light energy is delivered through the nasal cavity to stimulate brain tissues non-invasively, achieving therapeutic effects without the brain damage and cognitive deficits associated with electrical shock and surgical implants.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The nasal cavity serves as a natural intermediary pathway that allows light energy to reach the brain without requiring surgical intervention or direct tissue penetration. This intermediary approach eliminates the harmful effects of invasive methods while maintaining therapeutic effectiveness.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If deep brain stimulation is used, then specific brain areas can be targeted, but the procedure is invasive and requires surgical implantation

Engineering Contradiction:
Improvetargeting precisionVSAvoidinvasiveness and surgical requirement
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The nasal cavity insert is designed with specific geometric features and light directing elements that concentrate light energy on targeted brain regions. The insert's local quality design allows precise targeting without requiring surgical implantation, as the nasal cavity anatomy itself guides the light to the desired location.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The nasal cavity acts as a natural intermediary that provides precise targeting of brain regions through its anatomical structure. The light is directed through the nasal tissues to specific brain areas, achieving surgical-level precision without the invasiveness of DBS surgery.

Inventive Principle:
Principle #24Intermediary (Mediator)

4Adaptability or versatility

If cranial electrotherapy stimulation is used, then stress and anxiety can be treated, but the technique is experimental and lacks sufficient study

Engineering Contradiction:
Improvetreatment applicabilityVSAvoidscientific validity
Core Design Contradiction:
Adaptability or versatilityVSReliability

Solution Approach 1:

The invention replaces experimental electrical stimulation with light-based stimulation that has more robust scientific foundations. Light therapy through the nasal cavity is based on well-established photobiomodulation principles that have been studied extensively, providing both versatility in treating various conditions and stronger scientific validity.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system allows adjustment of light parameters (wavelength, intensity, duration) to optimize treatment for different conditions. This parameter flexibility enables the same device to treat various mental health conditions with varying efficacy, supported by solid scientific research on photobiomodulation mechanisms.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method provides safe, effective, and versatile brain stimulation with minimal side effects, offering a portable, cost-effective, and user-friendly solution for various therapeutic outcomes without invasiveness, overcoming the limitations of existing techniques.

Implementation Method 1

at least one light generating unit entirely housed and contained within said internal spatial volume of said hollow casing and which is capable of generating light energy of at least one preselected wavelength selected from the group consisting of near infrared red light wavelengths and visible red light wavelengths

Methodology Applied
Scientific EffectLight Emitting Diode: Light Emitting Diode

Implementation Method 2

capable of generating light energy... sufficient to penetrate through the nasal tissues and to pass into the brain

Methodology Applied
Scientific EffectLight penetration through tissue: Absorption (EM radiation)

Data Source

PatentEP3003481B1Self-administrable system for non-invasive neurostimulation therapy of the brain
Publication Date: 2018.10.17 LIM CO LTD
  • EP3003481B1 patent drawingFigure 1
  • EP3003481B1 patent drawingFigure 2
  • EP3003481B1 patent drawingFigure 3

AI summary

The present invention is a portable non-invasive apparatus, system, and method for performing light therapy or photobiomodulation upon the brain tissues through the nostrils of a living mammalian subject for the medical purpose of stimulating the brain in-vivo. In marked difference to conventionally known therapeutic procedures, the present invention utilizes the intranasal pathway as the point of anatomic access; and follows established principles for the conceptual approach that irradiation of the brain tissue with low level light energy of certain fixed parameters would achieve major therapeutic effects in-vivo. In this manner, the present invention utilizes light energy of specified wavelengths, coherency, and pulsed mode to achieve therapeutic outcomes.