Integrated Intraocular Delivery Device with Dynamic Resistance
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Solution Overview
Problem
Current intravitreal injection devices are cumbersome, increase the risk of complications due to user error, and lack features for accurate and atraumatic drug delivery into the eye, posing challenges such as intraocular infection and trauma to ocular structures.
Innovation Solution
Development of integrated devices that combine features for safe, sterile, and accurate delivery of pharmaceutical formulations into the eye, including a housing for one-handed manipulation, a conduit with a dynamic resistance component, and an actuation mechanism for controlled drug injection, with optional features like a filter to remove air and minimize trauma.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If commercially available intravitreal injection devices are used, then intravitreal injections can be performed, but the devices lack features for exposing the injection site, stabilizing against the sclera, and controlling the angle and depth of injection, leading to increased procedure time and risk of complications
Solution Approach 1:
The patent integrates multiple functions (exposure, stabilization, angle control, depth control) into a single unified injection device structure, eliminating the need for separate components and reducing procedure time while maintaining injection accuracy
Solution Approach 2:
The injection device is designed with multi-functional features including an ocular contact surface for exposure, a stabilization mechanism against the sclera, and controls for injection angle and depth, allowing one device to perform multiple functions previously requiring separate tools
2Productivity
If multi-component systems are used for intravitreal injection, then injection functionality is provided, but the systems are time-consuming to set up and use, increasing procedure time and risk of complications
Solution Approach 1:
The patent combines multiple separate components (exposure mechanism, stabilization element, injection control) into a single integrated device that can be deployed as one unit, dramatically reducing setup time and procedural complexity
Solution Approach 2:
The device is designed with pre-configured features that are ready for immediate use, eliminating the need for assembly or preparation steps during the procedure
3Reliability
If conventional injection devices are used, then drug delivery into the eye is achieved, but there is increased risk of intraocular infection and trauma to ocular structures due to lack of stabilization and control features
Solution Approach 1:
The device incorporates self-stabilizing features and automatic positioning mechanisms that reduce dependence on user skill and minimize the risk of user error during the injection procedure
Solution Approach 2:
The ocular contact surface acts as an intermediary between the injection device and the eye, providing a stable interface that facilitates accurate positioning and reduces trauma to ocular structures
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The integrated devices enable precise and safe delivery of drugs into the eye, reducing the risk of complications like intraocular infection and trauma, while ensuring accurate placement and controlled pressure, thereby improving the efficacy of intravitreal injections.
Implementation Method 1
Some devices include features that filter pharmaceutical formulations injected into the eye
Data Source
AI summary
Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on the injector device, or on a portion of the injection device housing, or on a drug reservoir. Some devices may be removably attached to a drug reservoir, for example, through a luer connector. Other devices may comprise internal luer seal for securely connecting a drug conduit of the device to the luer cavity of a drug reservoir. Yet other devices may comprise a priming-enabling element to facilitate the drug priming of a shielded needle. Related methods and systems comprising the devices are also described.