Intraocular Irrigating Solution with Active Sulfur Molecules
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Solution Overview
Problem
In ophthalmic surgery, intraocular irrigating solutions can cause oxidative stress leading to issues like corneal opacity, lens opacity, and retinal cell death due to direct contact with intraocular tissues, resulting in decreased vision post-surgery.
Innovation Solution
An intraocular irrigating solution containing active sulfur molecules such as cysteine persulfide and glutathione persulfide, which exhibit high antioxidant activity, is used to protect intraocular tissues during surgery, reducing oxidative stress and enhancing safety.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If conventional intraocular irrigating solutions are used, then basic surgical irrigation is achieved, but oxidative stress causes tissue damage including corneal opacity, lens opacity, and retinal cell death
Solution Approach 1:
The patent converts the harmful oxidative stress into a beneficial effect by introducing active sulfur molecules (cysteine persulfide and glutathione persulfide) that generate controlled sulfur radicals. These radicals scavenge harmful reactive oxygen species while protecting intraocular tissues, effectively transforming the harmful oxidative environment into a protective antioxidant system
Solution Approach 2:
The patent changes the chemical composition parameters of the irrigating solution by incorporating specific concentrations of active sulfur molecules (0.01-1000 μM cysteine persulfide and/or 0.01-1000 μM glutathione persulfide). This parameter change fundamentally alters the redox properties of the solution, enabling it to actively neutralize oxidative stress rather than merely providing passive irrigation
2Stability of the object's composition
If stable antioxidants like glutathione derivatives are used, then calcium precipitation is suppressed, but antioxidant activity against oxidative stress is insufficient
Solution Approach 1:
The patent creates a composite antioxidant system by combining stable glutathione derivatives with active sulfur molecules (cysteine persulfide and glutathione persulfide). This composite formulation integrates the stability of glutathione with the high antioxidant activity of active sulfur, achieving both solution stability and potent protection against oxidative stress
Solution Approach 2:
The active sulfur molecules act as intermediaries that bridge the gap between stable but weak antioxidants and the need for strong antioxidant activity. The sulfur radicals generated from cysteine persulfide and glutathione persulfide serve as reactive intermediaries that efficiently scavenge reactive oxygen species while the parent compounds maintain solution stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively suppresses oxidative stress and minimizes tissue damage during and after surgery, improving surgical outcomes by providing high antioxidant activity and affinity with intraocular tissues.
Implementation Method 1
an active sulfur molecule such as CysSSH in vivo exhibits high antioxidant activity
Data Source
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AI summary
The present invention addresses the problem of providing an intraocular irrigating solution that allows the intraocular tissue to be sufficiently protected during ophthalmic surgery and further has high safety. The problem is solved by an intraocular irrigating solution containing at least one of active sulfur molecules of which examples include cysteine persulfide and glutathione persulfide.