Intrasaccular Device with Variable Porosity for Aneurysm Occlusion
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Solution Overview
Problem
Current methods for treating cerebral aneurysms are limited in their ability to effectively occlude and reinforce aneurysmal vessels, often resulting in rupture risks due to inadequate thrombosis and healing, particularly in cerebral aneurysms.
Innovation Solution
The development of an intrasaccular device with expandable components having varying porosities and shapes, which can be positioned and repositioned within an aneurysm to provide a tailored therapeutic effect, including the use of foam structures that expand upon deployment to occlude the aneurysm and promote thrombosis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods (guiding catheter, guidewire, compressed stent) are used to treat aneurysms, then the device can be delivered to the target location, but the ability to effectively occlude and reinforce the aneurysm is insufficient, leading to rupture risks
Solution Approach 1:
The device is divided into multiple independent expandable components (first expandable component, second expandable component, etc.) that can be delivered separately through the catheter and then expanded independently at the target location. This segmentation allows each component to be optimized for specific functions while maintaining overall system manageability.
Solution Approach 2:
The device transitions from a compressed, deliverable state within the catheter to an expanded, therapeutic state at the aneurysm location. The expandable components dynamically change their configuration from a compact form for delivery to a deployed form for occlusion and reinforcement, resolving the contradiction between delivery feasibility and therapeutic effectiveness.
2Adaptability or versatility
If a single uniform porosity structure is used in the intrasaccular device, then manufacturing is simplified, but the ability to provide tailored therapeutic effects and optimize thrombosis is reduced
Solution Approach 1:
Different sections of the intrasaccular device are assigned different porosity characteristics. The first section has a first average porosity optimized for one function (e.g., thrombosis promotion), while the second section has a second average porosity optimized for another function (e.g., blood flow control or structural support). This local differentiation enables tailored therapeutic effects while maintaining manufacturability through modular construction.
3Reliability
If the device uses multiple expandable components with different porosities and shapes, then the therapeutic effectiveness and adaptability are improved, but the device complexity and positioning difficulty increase
Solution Approach 1:
The device is segmented into multiple independent expandable components that can be delivered separately through the catheter. Each component can be independently positioned and expanded, allowing the operator to control the deployment sequence and position each component optimally within the aneurysm sac.
Solution Approach 2:
The components are designed to be expandable from a compressed delivery state to a deployed therapeutic state. This dynamic transformation allows the complex multi-component structure to be delivered through standard catheters and then configured at the target location, managing the complexity through temporal separation of delivery and deployment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively occludes aneurysms, reduces rupture risk, and promotes healing by creating a tailored porosity profile that enhances thrombosis and supports the aneurysmal wall, allowing for controlled blood flow and improved treatment outcomes.
Implementation Method 1
The development of an intrasaccular device with expandable components having varying porosities and shapes, which can be positioned and repositioned within an aneurysm to provide a tailored therapeutic effect, including the use of foam structures that expand upon deployment to occlude the aneurysm and promote thrombosis.
Data Source
AI summary
A system for treatment of an aneurysm includes an intrasaccular device that can be delivered using a catheter. The device can include at least one expandable structure adapted to transition from a compressed configuration to an expanded configuration when released into the aneurysm. The expandable structure can have a specific shape or porosity. Multiple expandable structures can also be used, in which case each of the expandable structures can have a unique shape or porosity profile. The morphology of the aneurysm and orientation of any connecting arteries can determine the type, size, shape, number, and porosity profile of the expandable structure used in treating the aneurysm.