Intrasaccular Flow Diverter Thin-Film Spheroid Aneurysm Treatment
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for aneurysms, such as coil embolization and covered stents, face challenges including limited applicability, risk of recanalization, foreign body reactions, and potential for ischemic complications due to material impermeability and bulkiness, especially in the neurovasculature.
Innovation Solution
Development of intrasaccular flow diverters comprising a wire structure with crimps and a thin-film mesh that expands radially to form a spheroid structure, allowing for tissue ingrowth and blood clotting, and optionally incorporating umbrella structures for enhanced deployment and tissue integration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If covered stents are used to treat aneurysms, then blood flow is diverted away from the aneurysm sac, but the stent materials add substantial bulk and are impermeable, causing foreign body reactions and ischemic complications
Solution Approach 1:
The patent employs a porous flow diverter structure that allows blood and cellular components to pass through while maintaining flow diversion functionality. This porosity enables tissue ingrowth through the device, reducing foreign body reactions and preventing ischemic complications by allowing nutrient and oxygen transport to adjacent tissues, directly addressing the harmful effects of impermeable covered stents
Solution Approach 2:
The patent utilizes a thin-film mesh structure that provides flow diversion coverage without the substantial bulk of traditional covered stents. This thin-film approach reduces the device profile for better vascular compatibility while maintaining the flow diversion function, and the flexibility allows for better conformability to the vessel wall, reducing foreign body reactions
2Reliability
If coil embolization is used to treat aneurysms, then the aneurysm sac is packed to limit blood flow, but the technique is only applicable to aneurysms with narrow neck regions and carries risk of recanalization
Solution Approach 1:
The patent designs a flow diverter device that can be deployed in various aneurysm configurations including wide-neck and bifurcation aneurysms, not limited to narrow-neck cases. The device provides both flow diversion and scaffolding functions, and can be adapted to different anatomical locations, significantly expanding the versatility compared to coil embolization which is restricted to specific aneurysm types
3Reliability
If impermeable covered stents are used, then flow diversion is achieved, but tissue in-growth is limited and blood clots may dislodge causing life-threatening complications
Solution Approach 1:
The porous structure of the flow diverter allows blood components to pass through and promotes tissue ingrowth into the device matrix. This tissue integration stabilizes the device while simultaneously preventing thrombus formation by allowing natural blood flow patterns and enabling fibrin deposition that anchors potential clots, eliminating the embolization risk associated with impermeable stents
Data Source
AI summary
An intrasaccular flow diverter includes a wire structure (e.g., a braided wire or a laser-cut hypotube), a thin-film mesh placed over the wire structure, and crimps fixing the thin-film mesh to the wire structure at each crimp. The wire structure and the thin-film mesh between adjacent crimps are expanded radially to form thin-film covered spheroid structures. When deployed in an aneurysm, the spheroid structures may volumetrically fill the aneurysm sac. An intrasaccular flow diverter with an umbrella structure includes a wire structure with a plurality of crimps along the wire structure, and a thin-film covered umbrella structure at one end of the wire structure. The wire structure between adjacent crimps is expanded radially to form a spheroid structure. When deployed in an aneurysm, the thin-film covered umbrella structure may cover the aneurysm neck.