Layered Intrasaccular Mesh for Aneurysm Flow Blocking Stability
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Solution Overview
Problem
Current treatments for cerebral aneurysms, such as stents and vaso-occlusive coils, face challenges in effectively blocking blood flow into aneurysms without causing inadvertent occlusion of small perforator vessels, migration, or deformation, particularly in the tortuous cerebral vasculature.
Innovation Solution
Intrasaccular occlusion devices with multiple layers, including a first layer covering the entire length and a second layer only at the proximal section, provide enhanced flow disruption and anchoring to resist migration, utilizing a combination of soft and stiff materials to conform to the aneurysm geometry and maintain stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If stents are used to maintain blood flow through the vessel, then blood flow is maintained, but blood pressure applied to the aneurysm interior is reduced insufficiently
Solution Approach 1:
The device divides the aneurysm treatment function into two parts: a stent component that maintains parent vessel patency and allows blood flow, and a separate occlusive component (coils, liquid embolic, or particles) that specifically targets the aneurysm interior to reduce pressure. This segmentation allows each component to optimize its function without compromising the other.
Solution Approach 2:
The device applies different properties to different locations: the stent portion maintains vascular patency in the parent vessel while the occlusive material is delivered locally into the aneurysm sac to create thrombosis. This local quality differentiation allows blood flow maintenance in the parent vessel while achieving pressure reduction within the aneurysm.
2Productivity
If covered stents or stent-grafts are used to treat cerebral aneurysms, then blood flow through the vessel is maintained, but small perforator vessels near the vascular defect are inadvertently occluded
Solution Approach 1:
The invention extracts the occlusive function from the stent structure itself, allowing the stent to perform only its primary function of maintaining parent vessel patency. The occlusive material (coils, liquid embolic, or particles) is delivered separately through the stent framework directly into the aneurysm, avoiding coverage of perforator vessels while achieving aneurysm isolation.
Solution Approach 2:
The stent acts as an intermediary delivery platform that allows selective access to the aneurysm interior while preserving perforator vessel patency. The stent framework provides a scaffold for delivering occlusive material into the aneurysm sac without blocking the small perforating vessels that arise from the parent vessel.
3Ease of operation
If current uncovered stents are used, then they can be delivered through microcatheters, but they do not block enough flow to cause clotting in the aneurysm
Solution Approach 1:
The device merges two separate functions into a single integrated system: the deliverable uncovered stent that maintains parent vessel patency, and the vaso-occlusive material (coils, liquid embolic, or particles) that blocks aneurysm inflow. The stent serves as both the delivery platform and the flow maintenance structure, while the occlusive material provides the flow blocking function.
Solution Approach 2:
The stent is deployed first through the microcatheter to establish the structural framework and maintain parent vessel patency. This preliminary action creates a scaffold that facilitates subsequent delivery of the occlusive material into the aneurysm, ensuring that flow blocking is achieved without compromising vessel integrity.
4Reliability
If vaso-occlusive coils are used to treat cerebral aneurysms, then they can block blood flow into the aneurysm, but they suffer from poor packing density, compaction, and migration
Solution Approach 1:
The invention creates a universal platform that can accommodate multiple types of occlusive materials (coils, liquid embolic agents, or particles) within the same stent framework. This multi-functionality allows selection of the most appropriate occlusive material for each specific aneurysm morphology while maintaining consistent structural support and stability through the stent.
Solution Approach 2:
The device combines two distinct material systems: the stent framework (typically metallic or polymer) that provides structural support and maintains vessel patency, and the occlusive material (coils, liquid embolic, or particles) that fills the aneurysm sac. This composite structure provides both mechanical stability and flow blocking functionality.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The devices effectively block blood flow into aneurysms, reducing the risk of rupture or vessel damage, while resisting migration and deformation, offering immediate occlusion and promoting thrombosis over time.
Implementation Method 1
a self-expanding resilient permeable shell
Implementation Method 2
promoting thrombosis over time
Data Source
Figure 1~2
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AI summary
Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant such as a permeable shell or mesh having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include additional mesh layers on either the inside or the outside of a first permeable shell. The distal portion of the device may be softer and deformable.