Intrasaccular Aneurysm Implant with Spatially Differentiated Coatings
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Solution Overview
Problem
Current treatments for cranial aneurysms, particularly those with wide necks or bifurcations, face challenges in preventing blood flow into the aneurysm while avoiding obstruction of the parent blood vessel, often requiring ancillary devices like stents, which increase treatment complexity and time.
Innovation Solution
A braided mesh implant with distinct coated regions, one coated to inhibit blood cell adhesion and another to promote it, is designed to occlude the aneurysm neck and promote thrombus formation within the aneurysm sac, reducing the need for additional devices and simplifying the treatment process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If embolic material is placed to promote thrombus formation within the aneurysm, then blood flow into the aneurysm is prevented, but the parent blood vessel may become obstructed
Solution Approach 1:
The implant incorporates distinct coated regions with different surface properties: a first coated region with blood cell adhesion promotion properties positioned within the aneurysm sac to promote thrombus formation, and a second coated region with blood cell adhesion inhibition properties positioned at the aneurysm neck to prevent parent vessel obstruction. This local differentiation of surface properties allows simultaneous achievement of effective aneurysm occlusion and parent vessel protection.
2Object-affected harmful factors
If ancillary devices like stents are used to cover the aneurysm entrance, then the parent blood vessel is protected from obstruction, but treatment time and complexity increase
Solution Approach 1:
The invention integrates the functions of ancillary protection devices and embolic material into a single unified implant structure. The implant combines a braided mesh framework with distinct coated regions that simultaneously provide parent vessel protection (through the adhesion-inhibiting second coated region at the neck) and aneurysm occlusion (through the adhesion-promoting first coated region within the sac). This merging eliminates the need for separate stents or flow diverters, thereby reducing treatment complexity and time.
3Reliability
If the aneurysm entrance is overpacked with embolic material, then blood flow into the aneurysm is effectively blocked, but blood flow in the parent vessel is impeded
Solution Approach 1:
The implant uses spatially differentiated coated regions to control blood cell adhesion: the first coated region within the aneurysm sac promotes adhesion to ensure effective inflow blockage, while the second coated region at the aneurysm neck inhibits adhesion to maintain smooth parent vessel blood flow. This local quality differentiation allows the system to achieve complete aneurysm occlusion without compromising parent vessel patency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The implant effectively inhibits blood flow into the aneurysm and promotes thrombosis within the sac, reducing the risk of clot formation in the parent vessel and simplifying the treatment procedure by eliminating the need for ancillary devices.
Implementation Method 1
One or more regions of the implant that are designed to be implanted in a position to contact blood from a parent blood vessel can be coated with a coating to inhibit blood cell adhesion
Implementation Method 2
One or more regions of the implant that are designed to be contained within the aneurysm sac can be coated, abraded, or otherwise modified to promote blood cell adhesion
Data Source
AI summary
An aneurysm intrasaccular implant is provided having one or more coated regions. The implant includes a braided mesh movable from a delivery configuration having a single-layer tubular shape sized to traverse a catheter to an implanted configuration sized to be implanted in an aneurysm sac. The braided mesh can include an anti-thrombogenic coating defining a first section along the length of the braided mesh. The braided mesh can include a cell adhesion coating defining a second section along the length of the braided mesh. In the delivery confirmation, the first section can be positioned distal to the second section within the catheter. The second section is invertible to the implanted configuration such that the second section is positioned within the aneurysm sac and the first section is positioned to occlude an aneurysm neck.