Retrievable Intravascular Neural Interface With Self-Expanding Scaffold
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Solution Overview
Problem
Existing nervous system implants are invasive, difficult to reposition, and lack mechanisms for transient deployment and retrieval, posing challenges in clinical applications.
Innovation Solution
A self-expanding metallic scaffolding system with a bioabsorbable center ring and flexible interposer, allowing for deployment, re-sheathing, and retrieval within blood vessels, featuring a retrievable and re-sheathable design with integrated electrodes and transducers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional stents are deployed to support vessel walls, then structural support is provided, but the devices become permanently implanted with no recourse for malposition or adverse reactions
Solution Approach 1:
The stent is designed with dynamic properties allowing it to transition between deployed and compressed states. The self-expanding structure can be dynamically re-compressed into the delivery catheter for retrieval or repositioning, enabling clinicians to adjust the device based on patient response or positioning accuracy.
Solution Approach 2:
The stent can be nested within the delivery catheter when not in use. This allows the deployed stent to be re-sheathed back into the delivery system for retrieval or repositioning, providing a mechanism to correct malposition or remove the device if adverse reactions occur.
2Reliability
If large volume implants are used for nervous system stimulation, then therapeutic effect is achieved, but the implantation procedure becomes highly invasive
Solution Approach 1:
The stent is constructed with a flexible, thin-walled structure that can be compressed into a small profile for delivery through minimally invasive catheter-based approaches. The flexible material allows the device to navigate vascular pathways and be deployed at the target site without requiring open surgery or large incisions.
Solution Approach 2:
The device transitions from a low-profile compressed state during delivery to a fully expanded three-dimensional structure at the implantation site. This dimensional transformation allows the implant to be delivered through small vascular access points while providing sufficient therapeutic volume when deployed.
3Adaptability or versatility
If vascular filters are designed for transient implantation, then removal capability is provided, but no mechanism exists for repositioning the device once deployed
Solution Approach 1:
The stent can be re-sheathed back into the delivery catheter after deployment. This nested configuration allows the device to be retrieved and repositioned to optimal locations, combining the benefits of transient implantation with repositioning capability.
Solution Approach 2:
The stent maintains dynamic properties after deployment, allowing it to be re-compressed and re-positioned within the vessel. This dynamic behavior enables clinicians to optimize device placement or relocate it if initial positioning is suboptimal.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables minimally invasive, repositionable, and retrievable nervous system interfaces that integrate with vascular structures, facilitating safe and controlled implantation and removal, with the potential for long-term therapeutic applications.
Implementation Method 1
a self-expanding metallic structure that can include a plurality of support struts and a plurality of connector elements
Implementation Method 2
A self-Expanding Metallic Structure can be provided with a Bioabsorbable Center Ring
Data Source
AI summary
An exemplary device (e.g., an intravascular prosthesis) can be provided which can comprise an expandable configuration (e.g., a housing) configured or structured to be inserted within a luminal biological structure (e.g., a blood vessel). The expandable configuration can include at least one self-expanding system which is (i) a wire system and/or a mesh system, and (ii) configured to include a plurality of apical connectors, a subset thereof connecting to a medial structure. The expandable configuration can also include at least one flexible interconnect system configured or structured to house (i) at least one integrated circuit, (ii) at least one electrode, and (iii) at least one transducer. Alternatively or additionally, the expandable configuration can comprise a medial structure connected to one or more of the apical connectors, and which is be dissolved within the tubular biological structure to nontoxic species over a controlled time frame. Exemplary methods can also be provided for installing such exemplary intravascular prosthesis within a luminal biological structure.