Intravascular Reperfusion Therapy Device with Adaptive Flow Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current reperfusion therapies following percutaneous coronary intervention (PCI) often result in reperfusion injury, characterized by inflammatory responses and oxidative damage, which can hinder the restoration of normal tissue function and blood flow in ischemic areas.
Innovation Solution
An intravascular reperfusion therapy system comprising a sensor, pump, and catheter with a lumen, which delivers fluid in a retrograde flow to generate back pressure in coronary veins, allowing for adaptive monitoring and control of reperfusion therapy through a processor circuit that adjusts fluid flow and pressure based on physiological data to minimize injury and enhance blood flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If reperfusion therapy is delivered to restore blood flow to ischemic tissue, then tissue health is improved, but reperfusion injury occurs causing inflammatory response and oxidative damage
Solution Approach 1:
The system performs preliminary assessment of reperfusion therapy effectiveness before completing the full therapy sequence. The processor circuit evaluates physiological data during fluid delivery to determine if therapeutic goals are achieved, allowing early termination or modification of therapy to prevent excessive inflammatory response and oxidative damage while maintaining tissue health benefits
Solution Approach 2:
The system continuously monitors physiological data (flow rate, pressure, temperature) during reperfusion therapy delivery and uses this feedback to dynamically adjust fluid delivery parameters. This closed-loop control optimizes blood flow restoration to ischemic tissue while preventing over-perfusion that would trigger reperfusion injury, thereby resolving the contradiction between therapeutic benefit and harmful effects
2Productivity
If fluid flow is increased to enhance reperfusion therapy delivery, then blood flow restoration is improved, but inflammatory response and oxidative damage increase
Solution Approach 1:
The system dynamically adjusts fluid delivery parameters (flow rate, pressure, temperature) based on real-time physiological data rather than using fixed predetermined settings. The processor circuit modifies delivery characteristics during therapy to optimize reperfusion effectiveness while preventing excessive flow that would trigger inflammatory response and oxidative damage
Solution Approach 2:
The system changes multiple physical parameters of fluid delivery including flow rate, pressure, and temperature based on assessed therapy progression. By adjusting these parameters dynamically, the system enhances reperfusion therapy delivery efficiency when needed while reducing parameters to prevent inflammatory response and oxidative damage, resolving the contradiction between productivity and harmful effects
3Adaptability or versatility
If continuous monitoring of physiological data is implemented, then reperfusion therapy control is optimized, but device complexity increases
Solution Approach 1:
The system uses a single integrated processor circuit that performs multiple functions: assessing reperfusion therapy effectiveness, determining therapy progression, controlling fluid delivery parameters, and evaluating when to terminate therapy. This multi-functional approach achieves optimized adaptable control without proportionally increasing device complexity, as one component handles multiple control tasks
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively reduces reperfusion injury by optimizing blood flow distribution and reducing inflammation, thereby improving tissue health and function beyond what is achieved with PCI alone.
Implementation Method 1
deliver the reperfusion therapy by directing flow of a fluid through the lumen using the pump. In particular, by using the pump to deliver fluid (e.g., having retrograde flow with respect to the blood flow in the vein) to the coronary vein, the intravascular reperfusion therapy device may generate a back pressure within the coronary vein
Implementation Method 2
the sensor (e.g., a sensing component), may sense physiological data (e.g., flow data, pressure data, and/or the like) representative of blood flow through the blood vessel
Data Source
AI summary
A system includes an intravascular reperfusion therapy device configured to be positioned within a coronary vein of a patient to deliver reperfusion therapy to a myocardium of a heart associated with the coronary vein. The intravascular reperfusion therapy device includes a sensor, a pump, and a catheter with a lumen. The intravascular reperfusion therapy device is configured to, using the pump, direct flow of a fluid through the lumen to deliver the reperfusion therapy. The system includes a processor circuit configured to receive, from the sensor, physiological data associated with blood flow through the coronary vein, determine, based on the physiological data, a progression of the reperfusion therapy; and control, based on the progression of the reperfusion therapy, the flow of the fluid through the lumen such that the reperfusion therapy is controlled.