Intravascular Tissue Disruption via High-Velocity Fluid Jet
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Solution Overview
Problem
Existing medical devices for delivering fluids to bodily tissues face challenges in precisely controlling fluid flow and minimizing tissue damage, particularly in delivering therapeutic agents to peripheral tissues while avoiding damage to the inner lumen walls.
Innovation Solution
A medical device with a distal delivery region featuring multiple fluid controls, allowing for selective regulation of fluid flow and volume release, including high-velocity jet delivery systems that can target specific tissues with minimal damage to the lumen walls, using a combination of fluid controls with different aperture configurations and expandable elements to manage fluid release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If high-velocity fluid jets are used to disrupt target tissue, then tissue disruption effectiveness is improved, but damage to the lumen wall increases
Solution Approach 1:
The device creates a focused high-velocity fluid jet that concentrates energy locally at the target tissue site while minimizing energy dispersion to surrounding areas. The jet is directed through a precisely positioned aperture in the distal tip, ensuring that high-velocity impact is localized only to the intended disruption zone beyond the lumen wall, thereby protecting the lumen wall from collateral damage.
Solution Approach 2:
The distal tip structure incorporates a nested configuration where the fluid aperture is integrated within a protective housing or tip structure. This nested design allows the high-velocity jet to be generated and directed through a controlled pathway that shields the lumen wall from direct exposure to the jet's full force, while still enabling effective tissue disruption at the target site.
2Adaptability or versatility
If multiple fluid controls are used to deliver therapeutic agents to different locations, then treatment versatility is improved, but device complexity increases
Solution Approach 1:
The device divides the fluid delivery system into multiple independent control units or apertures located at the distal tip. Each aperture can be independently activated or directed to deliver therapeutic agents to different locations or depths of tissue. This segmentation allows versatile multi-location treatment while keeping each individual control element relatively simple in design.
Solution Approach 2:
The distal tip structure is designed with multiple fluid controls that can serve various functions - delivering different therapeutic agents, targeting different tissue depths, or treating different anatomical locations. This multi-functional design consolidates what would otherwise require multiple separate devices into a single universal platform, reducing overall system complexity while maintaining treatment versatility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise control over fluid delivery, minimizing damage to the lumen walls while effectively remodeling target tissues, such as renal nerves, to treat conditions like hypertension, with improved consistency and reduced leakage, and the ability to refine tissue remodeling post-procedure.
Implementation Method 1
Moving the first control to the open configuration can comprise moving a first valve element with a first aperture therein relative to a second valve element with a second aperture therein until the apertures are in alignment
Implementation Method 2
Moving the first fluid control to the open configuration can cause the fluid to flow from the first control at a high velocity
Data Source
AI summary
Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.