Cosmetic Composition Using Inulin, Alpha-Glucan, Hops Extract and Lactobacillus Lysate
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Solution Overview
Problem
Existing skincare compositions do not effectively address the stimulation of epidermal cell growth in the presence of inflammatory bacteria agents and the improvement of the balance of the skin microbiome.
Innovation Solution
A composition comprising inulin, alpha-glucan, common hops extract, and lysate of a fermentation product of bacteria of the Lactobacillus genus, which works synergistically to stimulate epidermal cell growth and balance the skin microbiome.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional skincare compositions are used, then basic skin care functions are provided, but they do not effectively stimulate epidermal cell growth in the presence of inflammatory bacteria agents
Solution Approach 1:
The patent combines four distinct bioactive components (inulin, alpha-glucan, hops extract, and Lactobacillus ferment lysate) into a composite formulation. Each component contributes different mechanisms: inulin and alpha-glucan provide prebiotic effects, hops extract offers anti-inflammatory properties through xanthohumol, and Lactobacillus ferment lysate stimulates cell growth. This composite approach creates synergistic effects that overcome the limitations of single-ingredient conventional products.
Solution Approach 2:
The patent specifies optimized concentration ranges for each ingredient to achieve maximum efficacy: inulin (0.01-10%), alpha-glucan (0.01-10%), hops extract (0.001-1%), and Lactobacillus ferment lysate (0.001-1%). These parameter optimizations ensure the formulation effectively stimulates epidermal cell growth while maintaining safety and stability, representing a departure from conventional arbitrary concentrations.
2Reliability
If conventional compositions are used, then general skin maintenance is achieved, but they do not effectively improve the balance of the skin microbiome
Solution Approach 1:
The formulation employs prebiotic ingredients (inulin and alpha-glucan) that selectively nourish beneficial skin microorganisms, enabling the skin microbiome to self-regulate and restore balance. This approach allows the skin's natural microbial ecosystem to thrive with supportive nutrients rather than relying on broad-spectrum antimicrobials that disrupt microbial balance.
Solution Approach 2:
The Lactobacillus ferment lysate acts as a mediator between the external environment and the skin microbiome. It contains postbiotic metabolites and cell wall components that modulate immune responses and create a favorable environment for beneficial microbes while inhibiting pathogenic bacteria, thereby facilitating microbiome balance.
3Reliability
If higher concentrations of active ingredients are used to improve efficacy, then skin-soothing effects are enhanced, but product complexity and manufacturing difficulty increase
Solution Approach 1:
The patent establishes specific concentration ranges that optimize both efficacy and manufacturability. By defining precise parameters for each ingredient, the formulation achieves reliable skin-soothing effects without requiring excessive amounts of active components, thereby simplifying manufacturing processes and reducing formulation complexity.
Solution Approach 2:
Each ingredient in the formulation serves multiple functions: inulin and alpha-glucan act as prebiotics, humectants, and film-formers; hops extract provides anti-inflammatory, antimicrobial, and antioxidant effects; Lactobacillus ferment lysate offers cell growth stimulation and microbiome balancing. This multi-functionality reduces the need for additional separate ingredients, simplifying the overall formulation and manufacturing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves a stimulation of epidermal cell growth and improves the balance of the skin microbiome, even at low concentrations, providing a skin-soothing effect, reducing skin irritation, and maintaining skin health.
Implementation Method 1
As a natural prebiotic, it supports the growth of microorganisms that are beneficial to the skin, thereby strengthening its natural protective barrier.
Implementation Method 2
Inulin also has a moisturizing effect—it forms a protective film on the surface of the epidermis, which prevents excessive water loss.
Implementation Method 3
Common hops extract is able to activate bitter taste receptors (T2R) in the skin, especially in keratinocytes and fibroblasts.
Implementation Method 4
The lysate comprises both parabiotic agents (fragments of L. pentosus obtained by lysis) and postbiotics (molecules derived from the culture supernatant). This lysate stimulates the expression of antimicrobial peptides and TLR2 receptors present in the skin
Data Source
AI summary
The invention relates to a composition comprising a combination of inulin, alpha-glucan, extract of common hops (Humulus lupulus) and a lysate of a fermentation product of bacteria of the Lactobacillus genus. The invention also relates to the use of the composition and to cosmetic products using the composition.