Inulin Open Matrix Fast Dissolving Pharmaceutical Composition
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Solution Overview
Problem
Current fast dissolving pharmaceutical compositions do not achieve rapid enough disintegration in aqueous mediums or saliva, limiting the rapid release of active ingredients.
Innovation Solution
A pharmaceutical composition featuring an open matrix network of inulin that rapidly disintegrates upon contact with an aqueous solution or saliva, with at least 80% disintegration occurring within 10 seconds, utilizing a process involving a liquid preparation with an active ingredient and inulin, followed by sublimation to create a fast-dispersing dosage form.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If conventional fast dissolving pharmaceutical compositions are used, then the dosage form can be administered orally, but the disintegration time in aqueous medium or saliva is too slow (more than 10 seconds)
Solution Approach 1:
The patent employs a porous matrix network formed by inulin that creates an open structure with high porosity. This porous architecture allows rapid penetration of aqueous medium or saliva into the matrix, facilitating extremely fast disintegration within 10 seconds. The porous structure is achieved through controlled phase separation during freeze-drying, creating interconnected voids that accelerate fluid penetration and matrix breakdown.
Solution Approach 2:
The patent utilizes parameter changes during the freeze-drying process, specifically controlling freezing temperature, drying rate, and formulation composition to create an optimized matrix structure. By adjusting these parameters, the inulin forms a specific gel-network structure with controlled porosity and hydrophilicity, enabling rapid disintegration while maintaining structural integrity during storage.
2Speed
If the matrix is made highly porous to achieve fast disintegration, then dissolution speed improves, but structural stability during storage may be compromised
Solution Approach 1:
The patent uses inulin as a composite matrix material that combines multiple functional properties: it forms a gel-network structure providing structural stability, creates porous architecture enabling fast disintegration, and exhibits hydrophilic characteristics facilitating rapid wetting. The composite nature of inulin allows simultaneous achievement of structural integrity during storage and rapid dissolution upon contact with aqueous medium.
Solution Approach 2:
The freeze-drying process creates a pre-stabilized porous structure that is mechanically robust during storage but becomes labile upon hydration. The matrix is prepared in advance with a specific gel-network architecture that maintains structural integrity under dry storage conditions but rapidly collapses and disintegrates when exposed to moisture, providing beforehand cushioning against premature degradation while enabling fast dissolution.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition ensures rapid release of active ingredients, with up to 100% disintegration in less than 10 seconds, enhancing bioavailability and convenience in oral administration.
Implementation Method 1
The pharmaceutical composition may be obtained by subliming a solvent (e.g. water), for example in a freeze drying process, from a liquid preparation that comprises the active ingredient and the matrix forming agent(s) in solution.
Implementation Method 2
The pharmaceutical composition may be obtained by subliming a solvent (e.g. water), for example in a freeze drying process, from a liquid preparation
Data Source
AI summary
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises inulin.