Iodide Hydrogen Peroxide Mastitis Treatment
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for mastitis in ruminants often require milk discard due to antibiotic residues, leading to economic losses and resistance issues, while existing alternatives like nisin are ineffective against Gram-negative bacteria and biofilms, and other antimicrobial agents have limitations in efficacy and safety.
Innovation Solution
A composition of iodide and hydrogen peroxide, without a peroxidase enzyme, is administered intra-mammarily, effectively killing bacteria and biofilms without leaving residues in milk, thus allowing immediate milk processing and reducing antibiotic resistance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antibiotic therapies are used to treat mastitis, then bacterial infection is effectively controlled, but milk must be discarded during and after treatment due to antibiotic residues
Solution Approach 1:
The patent changes the chemical nature of the antimicrobial agent from antibiotics to a combination of iodide and hydrogen peroxide. This parameter change allows the treatment to be effective against bacterial infections while not requiring milk discard, as the composition does not leave harmful residues that would contaminate the food chain or interfere with dairy processing.
Solution Approach 2:
The patent employs a short-acting antimicrobial composition that eliminates the need for long withdrawal periods. The iodide and hydrogen peroxide combination provides effective treatment but clears from the system quickly, allowing milk to be safely processed immediately after treatment without the economic burden of extended milk discard periods.
2Reliability
If antibiotics are used to treat mastitis, then bacterial infection is controlled, but antibiotic residues affect the human food chain and promote bacterial resistance
Solution Approach 1:
The patent fundamentally changes the type of antimicrobial agent from antibiotics to a non-antibiotic composition consisting of iodide and hydrogen peroxide. This parameter change eliminates the problem of antibiotic residues entering the food chain and reduces the promotion of antibiotic-resistant bacteria, while still providing effective control of bacterial infections through a different mechanism of action.
3Object-affected harmful factors
If nisin is used as an alternative to antibiotics, then antibiotic residues are avoided, but the treatment is ineffective against Gram-negative bacteria and biofilms
Solution Approach 1:
The patent uses a composite antimicrobial system combining iodide and hydrogen peroxide together. This composite approach overcomes the limitations of single agents like nisin by providing broad-spectrum activity against both Gram-positive and Gram-negative bacteria, as well as effectiveness against biofilms, while still avoiding antibiotic residue issues.
Solution Approach 2:
The patent changes the chemical parameters of the antimicrobial agent from peptide-based (nisin) to a combination of iodide and hydrogen peroxide. This parameter change expands the spectrum of activity to include Gram-negative bacteria and biofilm-disrupting capabilities that nisin lacks, while maintaining the advantage of no antibiotic residues.
4Reliability
If antibiotics are used to treat mastitis, then infection is controlled, but treatment costs increase due to milk discard requirements
Solution Approach 1:
The patent changes the antimicrobial agent from antibiotics to iodide and hydrogen peroxide combination, which has different pharmacokinetic properties. This parameter change allows the treatment to be effective while clearing from the system quickly, enabling continuous milk production and processing without the productivity losses associated with antibiotic withdrawal periods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively treats mastitis and biofilm infections without inducing antibiotic resistance, ensuring milk quality for dairy processing and reducing economic losses by allowing continuous milk production.
Implementation Method 1
The presence of an antimicrobial activity in the composition is dependent on the presence of both the iodide and the hydrogen peroxide in the composition
Data Source
Figure 1a~2
Figure 3
AI summary
This invention relates to a method for preparing compositions for preventing or treating microbial infections, compositions suitable for use in such treatments and methods for treatment or prevention of infections. One such composition finds particular use in treating mastitis in ruminants. The composition is administered into the udder of an animal as a highly effective treatment for mastitis, or as a prophylactic therapy, by means of an intra-mammary infusion. The milk produced by the animal, during treatment using the composition and method of the invention, is free of residues, such as antibiotics, antimicrobial agents or antimicrobial proteins, which could affect its suitability for drinking or in the production of milk products, such as cheese or yoghurt. The compositions and methods arc also useful in treating and preventing lung infections; and infections in burns and wounds; and other infections caused by biofilms. The compositions may also be used on medical devices lo prevent infection.