Intraocular Lens Haptic Fixation for Stable Drug Delivery

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Solution Overview

Problem

Existing intraocular drug delivery systems face challenges in securing drug delivery components efficiently and robustly to intraocular lenses, leading to potential migration and instability.

Innovation Solution

A stabilized intraocular drug delivery system is designed with a drug delivery component that includes a fixation portion with an opening to receive a haptic, secured by a retention tab and gusset, inhibiting movement relative to the IOL assembly, and utilizing a polymer material for stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a drug delivery component is placed on the haptic of an intraocular lens, then therapeutic agents can be delivered to the eye, but the drug delivery component may migrate or move relative to the IOL assembly

Engineering Contradiction:

Improvestability of drug delivery componentVSAvoidcomplexity of securing mechanism

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The fixation portion is inserted through the haptic, creating a nested structure where the fixation portion resides within the haptic structure. The retention tab extends through an opening in the fixation portion and is secured by sutures, forming a nested configuration that prevents migration while maintaining simplicity

Inventive Principle:

Principle #7Nested doll (Nesting)

Solution Approach 2:

The retention tab is positioned and secured with sutures before final implantation, establishing the stable connection in advance. This preliminary securing action ensures that the drug delivery component maintains its position relative to the IOL assembly during and after implantation

Inventive Principle:

Principle #10Preliminary action

2Reliability

If existing securing methods are used to attach the drug delivery component to the IOL, then the component can be fixed, but migration and rotation may still occur

Engineering Contradiction:

Improveprevention of migrationVSAvoidease of securing drug delivery component

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The haptic is divided into functional segments: a proximal portion for IOL attachment, a distal portion for drug delivery component attachment, and a retention tab extending between them. This segmentation allows each portion to perform its specific function while working together to prevent migration

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The retention tab acts as an intermediary element between the haptic and the fixation portion. It extends through an opening in the fixation portion and is secured by sutures, mediating the connection and preventing both migration and rotation of the drug delivery component

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS20260069401A1Stabilized intraocular drug delivery systems and methods of use

Publication Date: 2026.03.12 SPYGLASS PHARM INC

AI summary

Embodiments disclosed herein generally relate to an intraocular lens including an anterior side, a posterior side opposite the anterior side, a lens bordered by an edge, and a pair of haptics including a first haptic extending radially outward from the edge of the lens at a first lens-haptic junction. The first haptic includes a first outer end, a first inner end, a first posterior surface extending from the first outer end to the first inner end on the posterior side, and a first radially extending member at the first lens-haptic junction that connects the first haptic to the edge of the lens. The first radially extending member includes a first relief cut on the posterior side that is anterior positioned relative to a posterior edge surface of the edge of the lens and the first posterior surface of the first haptic.