Iomeprol Synthesis via Inorganic Salt Separation
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Solution Overview
Problem
Existing methods for producing iomeprol, an X-ray contrast agent, face challenges in removing inorganic salts generated during the manufacturing process, requiring costly ion exchange resin treatment and prolonging the manufacturing time, which increases production costs and equipment needs.
Innovation Solution
A one-step synthesis process involving an N-methylation reaction with an inorganic base, inorganic chloride, and a solvent that dissolves inorganic chloride is used to prepare iomeprol, allowing for effective separation and removal of inorganic salts without the need for an ion exchange resin, thereby shortening the manufacturing time and enhancing purity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If ion exchange resin treatment is used to remove inorganic salts, then purity is improved, but device complexity and manufacturing cost increase
Solution Approach 1:
The patent extracts and removes inorganic salts from the reaction mixture through a specific purification step using a purification column filled with a porous polymer material, separating the inorganic salts from the organic product iomeprol without requiring complex ion exchange resin systems
Solution Approach 2:
The patent introduces a porous polymer material as an intermediary substance in the purification column that selectively interacts with inorganic salts while allowing the organic product to pass through, serving as a mediator between the reaction mixture and the purified product
2Manufacturing precision
If ion exchange resin treatment is used to remove inorganic salts, then purity is improved, but manufacturing time increases
Solution Approach 1:
The patent segments the purification process into a distinct step using a purification column with porous polymer material, allowing the main reaction to proceed efficiently while the purification is handled separately in a optimized manner, reducing the overall time required compared to using ion exchange resin
3Manufacturing precision
If multiple synthesis steps are used, then purity is improved, but productivity decreases
Solution Approach 1:
The patent merges the N-methylation reaction and purification steps into a more integrated process where the reaction is performed in a solvent system that facilitates easier separation, combining operations to reduce the total number of discrete steps while maintaining high purity through the porous polymer purification column
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method significantly reduces manufacturing time, minimizes impurities, and achieves high-purity iomeprol production of 99% or more by dissolving inorganic chloride in the reaction solvent and crystallization solvent, eliminating the need for ion exchange resin treatment.
Implementation Method 1
performing N-methylation reaction by adding an inorganic base, an inorganic chloride and a solvent that dissolves inorganic chloride to 5-(2-hydroxyacetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
Implementation Method 2
adding an inorganic base, an inorganic chloride and a solvent that dissolves inorganic chloride
Implementation Method 3
crystallization solvent, thereby shortening the manufacturing time and enhancing purity
Data Source
AI summary
The present invention relates to a method for preparing an X-ray contrast agent iomeprol and, more specifically, to a method for preparing iomeprol by adding an inorganic base, an inorganic chloride, a solvent, etc. to 5-(2-hydroxyacetamido)-N, N'-bis(2, 3-dihydroxypropyl)-2, 4, 6-triiodoisophthalamide (1b) to cause N-methylation reaction, thereby enabling easy separation and removal of inorganic salts generated during the reaction, without treatment with an ion exchange resin, while reducing the conventional production time, and minimization of the amount of reaction impurities.