Ion Detection Amplifier Compensation With Remote High-Voltage Tuning

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Solution Overview

Problem

High-resistance resistors used in ion detectors for mass spectrometers suffer from non-linear behavior due to parasitic capacitances and dielectric relaxation, affecting measurement accuracy, and manually adjustable digital potentiometers cannot handle high ion detection voltages.

Innovation Solution

A conversion circuit with a voltage reduction circuit and neutralizing amplifier is used to reduce ion detection voltage to within the operating range of commercially available components, allowing remote adjustment of compensation voltages using digital variable resistors, and additional RC circuits compensate for time-varying deviations.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If manually operated potentiometers are used to adjust compensation voltages, then the compensation can be tuned, but it requires a substantial amount of time and manual intervention, reducing operational efficiency

Engineering Contradiction:
Improvecompensation accuracyVSAvoidoperational efficiency
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

Manual potentiometers are replaced with digitally controllable resistors that can be adjusted remotely via digital interfaces. The digital control system substitutes the mechanical adjustment mechanism, allowing compensation parameters to be tuned through software or automated routines. This eliminates the need for manual intervention while maintaining the ability to precisely adjust compensation voltages, thereby improving operational efficiency without sacrificing compensation accuracy

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system incorporates automated tuning capabilities where the compensation parameters can be self-adjusted based on predefined criteria or calibration routines. The digital control system enables the compensation circuit to self-optimize without requiring manual intervention, making the system self-sufficient in maintaining optimal performance across varying operating conditions

Inventive Principle:
Principle #25Self-service

2Ease of operation

If digital potentiometers are used to enable remote adjustment of compensation voltages, then operational convenience is improved, but the maximum voltage that can be applied is limited, making them incompatible with high ion detection voltages of 50 V or 100 V

Engineering Contradiction:
Improveremote adjustabilityVSAvoidvoltage compatibility
Core Design Contradiction:
Ease of operationVSAdaptability or versatility

Solution Approach 1:

The high voltage compensation circuit is segmented into multiple stages, each operating at lower voltage levels compatible with digital potentiometers. Voltage dividers are used to step down the high ion detection voltage to levels that digital potentiometers can handle, while still maintaining the ability to compensate for the full voltage range. This segmentation allows remote adjustability to be maintained while expanding voltage compatibility

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Voltage dividers and isolation circuits are introduced as intermediaries between the high-voltage ion detection circuit and the low-voltage digital potentiometers. These intermediary circuits translate the high voltage signals into compatible low voltage levels for the digital potentiometers while preserving the compensation functionality. This allows digital potentiometers to be used in high-voltage applications without exceeding their voltage ratings

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Accurately compensates for non-ideal resistor characteristics, enabling precise ion detection even at high voltages, and allows remote tuning of compensation settings.

Implementation Method 1

a voltage reduction circuit for deriving a reduced (ion detection) voltage from the ion detection voltage

Methodology Applied
Scientific EffectVoltage division: Ohm's Law

Implementation Method 2

By providing at least one neutralizing amplifier for neutralizing this reduction of the voltage, the effectiveness of the capacitive compensation element(s) is not hampered

Methodology Applied
Scientific EffectElectrical amplification:

Implementation Method 3

The capacitive compensation elements of the resistor assembly disclosed in US 9,431,976 may be conductive rings arranged around but electrically isolated from the high-resistance resistor. The rings constitute capacitances, to which compensation voltages are applied. Thus, the parasitic capacitances of the high-resistance resistor can be compensated

Methodology Applied
Scientific EffectCapacitance compensation: Capacitance

Implementation Method 4

additional RC circuits compensate for time-varying deviations

Methodology Applied
Scientific EffectRC time constant filtering: Capacitance

Data Source

PatentEP4009518B1Spectrometer amplifier compensation
Publication Date: 2026.01.28 THERMO FISHER SCI BREMEN
  • EP4009518B1 patent drawingFigure 1
  • EP4009518B1 patent drawingFigure 2
  • EP4009518B1 patent drawingFigure 3~4

AI summary

An ion detection current conversion circuit (153) comprises: - a conversion amplifier (152) coupled with a conversion resistor assembly for converting an ion detection current produced by an ion detector into an ion detection voltage, the conversion resistor assembly comprising a resistor (151) having a high resistance and a capacitive compensation element (157), and - a compensation voltage circuit (158) for deriving a compensation voltage (Vcomp) from the ion detection voltage (Vout) and feeding the compensation voltage to the capacitive compensation element (157), the compensation voltage circuit comprising a variable resistor (201) for adjusting the compensation voltage. The conversion circuit may further comprise a voltage reduction circuit (R15, R16, 220) for deriving a reduced voltage (Vred) from the ion detection voltage (Vout) and a neutralizing amplifier unit (211) for at least partially neutralizing the voltage reduction of the voltage reduction circuit. The reduced voltage allows low-voltage components, such as digital variable resistors, to be used.