Ion Exchange Separation of Mono- and Di-Carboxylic Acids

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Solution Overview

Problem

Current methods for separating mono- and di-carboxylic acid compounds from mixtures, such as those produced from crude oil or biorenewable sources, often require strong inorganic acids, leading to high costs, environmental concerns, and the need for specialized equipment and materials, which can impact process efficiency and product purity.

Innovation Solution

A process using ion exchange chromatography with organic acids as eluents, specifically acetic acid, to selectively elute mono- and di-carboxylic acid compounds, allowing for their separation without the use of strong acids, thereby reducing costs and environmental impact while maintaining high separation efficiency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If strong inorganic acids are used for separation, then separation effectiveness is improved, but equipment complexity and operational costs increase

Engineering Contradiction:
Improveseparation effectivenessVSAvoidequipment complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent uses ion-exchange resin as an intermediary substance to facilitate the separation of mono- and di-carboxylic acids. The resin selectively binds to di-carboxylic acids through ionic interactions, allowing mono-carboxylic acids to pass through in the permeate while di-carboxylic acids remain in the retentate. This intermediary mechanism replaces the need for complex equipment and strong inorganic acids, achieving effective separation through the resin's selective binding properties.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Manufacturing precision

If strong inorganic acids are used for separation, then separation effectiveness is improved, but operational costs increase

Engineering Contradiction:
Improveseparation effectivenessVSAvoidoperational costs
Core Design Contradiction:
Manufacturing precisionVSEase of manufacture

Solution Approach 1:

The patent employs ion-exchange resin that can be used in a cost-effective manner. The resin is loaded onto a support matrix and can be regenerated or replaced relatively easily compared to the high costs associated with strong inorganic acids and specialized equipment. This approach reduces operational costs by using a more economical separation medium that does not require expensive handling infrastructure.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

3Manufacturing precision

If strong inorganic acids are used for separation, then separation effectiveness is improved, but environmental impact worsens

Engineering Contradiction:
Improveseparation effectivenessVSAvoidenvironmental impact
Core Design Contradiction:
Manufacturing precisionVSObject-affected harmful factors

Solution Approach 1:

The patent converts the potentially harmful use of strong inorganic acids into a benign process using ion-exchange resin. The resin performs the separation function without introducing harmful chemicals into the system. The eluents used (water, alcohol, or mild acids) are environmentally friendly compared to strong inorganic acids, thus eliminating the environmental harm while maintaining separation effectiveness.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

4Manufacturing precision

If strong inorganic acids are used for separation, then separation effectiveness is improved, but process safety worsens

Engineering Contradiction:
Improveseparation effectivenessVSAvoidprocess safety
Core Design Contradiction:
Manufacturing precisionVSObject-affected harmful factors

Solution Approach 1:

The ion-exchange resin acts as a safe intermediary that enables separation without requiring hazardous strong inorganic acids. The resin's selective binding capability provides the necessary separation effectiveness while the process uses safe eluents such as water, alcohol, or mild acids, thereby improving process safety by eliminating the need to handle corrosive and dangerous chemicals.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The process effectively separates mono- and di-carboxylic acid compounds, achieving high purity and reducing the need for specialized materials and handling of strong acids, thus enhancing the commercial viability and environmental sustainability of the separation process.

Implementation Method 1

contacting the mixture with an ion exchange chromatography medium to cause at least one mono-carboxylic acid compound and at least one di-carboxylic acid compound to be retained by the ion exchange chromatography medium

Methodology Applied
Scientific EffectIon exchange: Ion Exchange

Implementation Method 2

eluting at least one mono-carboxylic acid compound from the ion exchange chromatography medium using a first eluent to form a first eluate; and eluting at least one di-carboxylic acid compound from the ion exchange chromatography medium using a second eluent to form a second eluate

Methodology Applied
Scientific EffectDesorption: Desorption

Data Source

PatentUS9487465B2Process for the separation of mono- and di-carboxylic acid compounds
Publication Date: 2016.11.08 ARCHER DANIELS MIDLAND CO
  • US9487465B2 patent drawing
  • US9487465B2 patent drawing
  • US9487465B2 patent drawing

AI summary

The present disclosure relates to processes for the separation of at least one di-carboxylic acid compound and/or at least one mono-carboxylic acid compound from a mixture. The separation processes involve contacting the mixture with an ion exchange medium to cause at least one of the mono- and/or di-carboxylic acid compounds to be retained by the medium, eluting at least one of the mono-carboxylic acid compound or the di-carboxylic acid compound using an eluent to form an eluate, wherein the eluate is enriched in at least one of the mono-carboxylic acid compound or di-carboxylic acid relative to the concentration of such eluted acid in the mixture having contacted the medium and wherein the eluent comprises an organic acid. The process has particular utility in the production of di-carboxylic acid compounds from glucose.