Ion-Substituted Hollow Calcium Phosphate Particles for Dental Stability
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Solution Overview
Problem
Current calcium phosphate particles used in dental applications are unstable and prone to crystallization, which reduces their bioactivity and effectiveness in promoting remineralization and occluding dentin tubules, leading to inadequate treatment of dentin hypersensitivity and enamel demineralization.
Innovation Solution
Development of hollow calcium phosphate particles with a shell comprising calcium, phosphate, magnesium, and strontium, which are X-ray amorphous and stable, manufactured through a method involving the mixing of salt solutions and heating to form a core-shell structure that maintains morphology and bioactivity during storage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional calcium phosphate particles are used, then they can provide remineralization and dentin tubule occlusion, but they are unstable and prone to crystallization which reduces their bioactivity and effectiveness
Solution Approach 1:
The patent changes the compositional parameters by incorporating magnesium and strontium ions into the calcium phosphate structure, creating ion-substituted calcium phosphate particles. This substitution modifies the crystal lattice parameters and destabilizes the crystalline phase, maintaining the particles in an amorphous or poorly crystalline state that resists crystallization during storage while preserving bioactivity for remineralization and tubule occlusion.
Solution Approach 2:
The patent creates a composite material system by combining calcium phosphate with magnesium and strontium elements. This multi-element composition forms a complex structure where the interaction between different ions stabilizes the amorphous phase and prevents transformation to crystalline forms, thereby maintaining both stability and bioactivity over time.
2Quantity of substance
If calcium phosphate particles are used to promote remineralization, then additional calcium and phosphate ions are required, but the particles must maintain stability without significant crystallization during storage
Solution Approach 1:
The patent modifies the chemical composition parameters by substituting calcium ions with magnesium and strontium ions in controlled amounts. This substitution maintains the particle's ability to release calcium and phosphate ions for remineralization while simultaneously stabilizing the amorphous structure against crystallization during extended storage periods.
Solution Approach 2:
The patent creates particles that are stable during storage but remain bioactive and capable of ion release during use. The ion-substituted structure allows the particles to maintain their amorphous state indefinitely in storage, then transition to releasing ions when applied to teeth, effectively separating the storage stability requirement from the functional activity requirement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hollow calcium phosphate particles effectively prevent and treat dentin hypersensitivity, enamel demineralization, and caries by maintaining stability and bioactivity, allowing for prolonged use in oral care products such as toothpastes and gels without significant crystallization.
Implementation Method 1
The method is based on precipitation of particles from a buffered solution under static, stirring, or hydrothermal conditions
Implementation Method 2
The particles are X-ray amorphous and stable, manufactured through a method involving the mixing of salt solutions and heating to form a core-shell structure that maintains morphology and bioactivity during storage
Data Source
AI summary
The present invention relates to hollow calcium phosphate particles comprising a respective shell comprising calcium, phosphate, water, magnesium, and strontium. The particles have a mean diameter ranging from 400 nm to 1.5 μm. The invention also relates to methods of producing such particles and compositions comprising such particles.