Ion Trap Mass Spectrometer ECD CID Isolation
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Solution Overview
Problem
Current methods for Electron Capture Dissociation (ECD) and Collision Induced Dissociation (CID) in mass spectrometry require strong magnetic fields, leading to costly equipment and maintenance, and lack efficient isolation techniques before and after reactions.
Innovation Solution
An RF linear-trap with a multipole field, DC harmonic potential, and electron source for precise isolation, ECD, and CID, using a magnetic field of 1 Tesla or more, and supplemental AC voltages for resonance and dissociation without magnetic field influence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a strong magnetic field of 1 Tesla or more is used for ECD, then ion trapping efficiency is improved, but equipment cost and maintenance expense increase due to superconducting magnet requirements
Solution Approach 1:
The patent changes the magnetic field strength parameter from strong (1 Tesla or more) to weak (a few hundred millitesla or less), making the system compatible with conventional magnets instead of requiring superconducting magnets, thereby reducing equipment cost and maintenance while maintaining ion trapping functionality
Solution Approach 2:
The patent replaces expensive superconducting magnets with conventional, cheaper magnets by adjusting the operating parameters (weak magnetic field compatibility), effectively using a more economical component substitution approach
2Reliability
If a weak magnetic field is superimposed in the axial direction of the RF linear-trap, then ion trapping in the radial direction is maintained, but energy deposition onto electrons from the RF electric field is suppressed
Solution Approach 1:
The patent adjusts the magnetic field strength parameter to an optimal range (a few hundred millitesla or less) that simultaneously maintains ion trapping stability while allowing sufficient electron energy deposition from RF electric field for effective ECD reactions
3Manufacturing precision
If resonance conditions and boundary conditions in RF electric field are used for isolation and CID, then ion separation is achieved, but stable trapping condition is split and precise isolation and CID cannot be performed
Solution Approach 1:
The patent performs isolation before ECD reaction by resonantly ejecting specific ions, and performs CID after ECD reaction, sequencing these operations to maintain stable trapping conditions throughout the process while achieving precise ion separation and dissociation
Solution Approach 2:
The patent dynamically adjusts the RF electric field parameters and magnetic field strength to maintain stable trapping conditions during sequential operations of isolation, ECD, and CID, adapting the field conditions at each stage to preserve trapping stability while achieving the desired ion manipulation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables highly accurate and efficient ECD and CID with reduced equipment costs and improved isolation capabilities, independent of magnetic field interference.
Implementation Method 1
a means for generating a magnetic field in the axial direction of the ion-trap
Implementation Method 2
a means for creating a DC harmonic potential in the axial direction of the ion-trap
Implementation Method 3
Electron Capture Dissociation (ECD) occurs by injecting low energy ions with 1 eV or less in a strong magnetic field
Implementation Method 4
an ion-trap which has a plurality of rod electrodes and creates a multipole field
Data Source
AI summary
An ion trap in which highly accurate isolation, ECD, and CID can be efficiently performed. A reaction cell and a mass spectrometer of the present invention include an ion-trap which has a plurality of rod electrodes and creates a multipole field, a means for generating a magnetic field in the axial direction of the ion-trap, a means for creating a DC harmonic potential in the axial direction of the ion-trap, and an electron source for introducing electrons into the central axis of the ion-trap. The identification ability is greatly improved compared with the prior art.