Transdermal Ionic Liquid Peptide Adjuvant Delivery
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Solution Overview
Problem
Conventional cancer vaccines face challenges in delivering cancer antigenic peptides and adjuvants transdermally due to the skin's strong barrier function, limiting their permeability and effectiveness in activating immune responses.
Innovation Solution
A combined preparation comprising a first transdermal administration of an antigenic peptide and an aliphatic carboxylic acid-based ionic liquid, and a second transdermal administration of an adjuvant in the same ionic liquid, enhancing skin permeability and immune response activation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional transdermal administration of cancer antigenic peptides and adjuvants is used, then the skin barrier function is maintained, but the permeability and delivery efficiency to APCs is insufficient
Solution Approach 1:
The invention segments the vaccine components into two separate preparations: one containing the cancer antigenic peptide and another containing the adjuvant. Both preparations use ionic liquids as carriers and are administered separately to the skin, allowing each component to be optimized for its own delivery while working together to achieve the desired immune response.
Solution Approach 2:
The invention introduces ionic liquids as intermediary carrier substances that facilitate the transdermal delivery of both the antigenic peptide and adjuvant. The ionic liquids act as mediators that enhance skin permeability without compromising the skin barrier, enabling efficient delivery of the vaccine components to antigen-presenting cells.
2Productivity
If transdermal absorption enhancers are used to improve peptide permeability, then the delivery to APCs is enhanced, but the skin barrier function is compromised
Solution Approach 1:
The invention changes the physical and chemical parameters of the carrier substance by using ionic liquids with specific properties (viscosity, conductivity, solubility). By carefully selecting ionic liquid components and their ratios, the formulation achieves optimal skin permeability enhancement while maintaining skin barrier integrity through controlled parameter optimization.
3Ease of operation
If cancer antigenic peptide and adjuvant are administered together in the same composition, then the administration process is simplified, but the skin permeability and immune response activation are insufficient
Solution Approach 1:
The invention divides the vaccine into two separate preparations administered in sequence or simultaneously to different skin areas. This segmentation allows each component (antigenic peptide and adjuvant) to be delivered with optimized formulation characteristics, resulting in enhanced immune response activation compared to combined administration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly increases the penetration of antigenic peptides and adjuvants through the skin, effectively inducing cytotoxic T lymphocytes and inhibiting tumor growth, making it suitable for treating cancers like skin and lung cancer.
Implementation Method 1
it has been desired to develop a preparation for transdermal administration suitable for the delivery to Langerhans cells... transdermal absorption enhancers for enhancing the permeability of cancer antigenic peptide to the stratum corneum
Implementation Method 2
the skin permeability of both an antigenic peptide and an adjuvant is improved by not administering a preparation comprising both an antigenic peptide and an adjuvant but preparing each preparation for transdermal administration in which an antigenic peptide and an adjuvant are separately dissolved in an aliphatic carboxylic acid-based ionic liquid, which acts as a transdermal absorption enhancer
Data Source
AI summary
The present invention is to provide a combined preparation comprising a first preparation for transdermal administration comprising an antigenic peptide and an aliphatic carboxylic acid-based ionic liquid, and a second preparation for transdermal administration comprising an adjuvant and an aliphatic carboxylic acid-based ionic liquid, enhances the skin permeability of an antigenic peptide and an adjuvant and thus effectively enhances the effect of activating the immune response with the antigenic peptide by the use of the adjuvant.