Ionic Liquid Protein Delivery Composition for Polypeptide Stability

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Solution Overview

Problem

Ionic liquids destabilize large polypeptides during drug delivery, leading to a form or conformation that negatively impacts the drug's efficacy.

Innovation Solution

A composition comprising an ionic liquid and a non-ionic surfactant, specifically Choline And Geranate (CAGE) with polysorbate, is used to stabilize large polypeptides during delivery, maintaining drug efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If ionic liquids are used for drug delivery, then delivery ability is improved, but polypeptide stability deteriorates

Engineering Contradiction:

Improvedrug delivery abilityVSAvoidpolypeptide stability

Core Design Contradiction:

ProductivityVSStability of the object's composition

Solution Approach 1:

The patent introduces a non-ionic surfactant as an intermediary substance that mediates between the ionic liquid and the polypeptide. The surfactant forms a protective interface around the polypeptide, allowing the ionic liquid to enhance delivery while the surfactant prevents direct destabilizing interactions, thus resolving the contradiction between improved delivery and maintained stability

Inventive Principle:

Principle #24Intermediary (Mediator)

2Ease of operation

If ionic liquids are used to enhance delivery, then transdermal delivery is improved, but polypeptide conformation deteriorates

Engineering Contradiction:

Improvetransdermal deliveryVSAvoidpolypeptide conformation

Core Design Contradiction:

Ease of operationVSShape

Solution Approach 1:

The patent applies beforehand cushioning by incorporating the non-ionic surfactant into the formulation prior to delivery. The surfactant pre-establishes a protective environment around the polypeptide, cushioning it against conformational damage that would otherwise occur during transdermal delivery through the ionic liquid medium

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination of ionic liquid and non-ionic surfactant provides excellent drug delivery characteristics while ensuring superior stability of large polypeptides, such as antibodies.

Implementation Method 1

a. an ionic liquid; and b. at least one non-ionic surfactant

Methodology Applied

Scientific EffectSurfactant: Surfactant

Data Source

PatentUS12533315B2Compositions comprising at least one ionic liquid, a polypeptide, and at least one non-ionic surfactant for protein delivery

Publication Date: 2026.01.27 PRESIDENT & FELLOWS OF HARVARD COLLEGE

AI summary

The technology described herein is directed to methods and compositions for drug delivery, e.g., comprising an ionic liquid and a non-ionic surfactant.