Functionalized Ionic Silicones for Drug Delivery and Wound Care
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current ionic silicones lack the necessary hydrophilicity and flexibility for applications such as wound care and drug delivery, where hydrophilic active agents tend to crystallize, reducing their effectiveness, and existing polymers are brittle, leading to issues like fertilizer premature release and coating cracking.
Innovation Solution
Development of functionalized ionic silicone compositions with specific ionic groups like sulfonate, sulfate, and phosphate, which provide hydrophilicity, flexibility, and controlled release capabilities, suitable for various applications including wound care, drug delivery, and agricultural uses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional ionic silicones are used, then basic ionic functionality is provided, but hydrophilicity is insufficient and drug crystallization occurs
Solution Approach 1:
The patent combines multiple ionic groups (sulfonate, sulfate, phosphate) with silicone backbone to create a composite material that integrates the hydrophobic stability of silicones with the hydrophilic properties of ionic groups, preventing drug crystallization while maintaining structural integrity
Solution Approach 2:
The patent modifies the chemical parameters of silicone by introducing specific ionic groups (sulfonate, sulfate, phosphate) at controlled concentrations, transforming the material from hydrophobic to hydrophilic and preventing drug crystallization
2Strength
If existing polymers are used for coating, then coating formation is achieved, but brittleness causes cracking and premature fertilizer release
Solution Approach 1:
The patent changes the mechanical parameters of the polymer by incorporating ionic groups that increase chain flexibility and elasticity, transforming brittle coatings into flexible, crack-resistant films that maintain integrity while controlling fertilizer release
3Adaptability or versatility
If functionalized ionic silicones are developed, then hydrophilicity and flexibility are improved, but formulation complexity increases
Solution Approach 1:
The patent creates a universal silicone platform with multiple ionic group options (sulfonate, sulfate, phosphate) that can serve various applications (wound care, drug delivery, agriculture) through a single base formulation, reducing overall formulation complexity despite increased versatility
Data Source
AI summary
There is provided herein a functionalized ionic silicone composition comprising a silicone of the formula (I): M1a M2b M3cD1d D2e D3f T1g T2h T3i Qj (I) which contains a monovalent radical bearing ion-pairs and having the formula (II): -A-lx-"Mny+; where A is a spacing group having at least 2 spacing atoms selected from a divalent hydrocarbon or hydrocarbonoxy group, where I is an ionic group such as sulfonate-S03-, carboxylate -COO-, phosphonate -PO32- group and phosphate - OPO32-, where M is hydrogen or a cation independently selected from alkali metals, alkali earth metals, transition metals, metals, quaternary ammonium and phosphonium groups; or, zwitterions having the formula (III): -R'-NR"2+-R'"-I (III) where I is defined as above, and where the subscript a, b, c, d, e, f, g, h, i, j are zero or positive subject to the following limitations: 2≤ a+b+c+d+e+f+g+h+i+j ≤ 6000, b+e+h >0 and c+f+i >0.