Ionization Probe Connection Jig for Liquid Chromatograph Alignment
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Solution Overview
Problem
In liquid chromatograph mass spectrometers, particularly micro-ESI or nano-ESI systems, the inefficient connection of the ionization probe to the column due to the need for manual screwing in a narrow space reduces work efficiency, and integrated configurations that eliminate user connection issues restrict column removal and adjustment.
Innovation Solution
An ionization probe connection jig with a first element fixture attached to either the column or ionization probe, a second element fixture attached to the other, and a movement regulating tool to align and secure the flow paths for face abutment connection, allowing easy connection without screwing into a narrow space and enabling column removal.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the column and ionization probe are connected by manual screwing in a narrow space, then the connection is secure, but the work efficiency is reduced
Solution Approach 1:
The patent introduces a connection jig as an intermediary tool between the column and ionization probe. The jig includes a push-in member with a pressing portion that automatically presses the column outlet against the probe inlet when pushed, eliminating the need for manual screwing operations in narrow spaces while ensuring secure connection through controlled pressing force.
Solution Approach 2:
The connection jig enables self-service connection where the user simply pushes the jig, and the pressing mechanism automatically performs the connection task. The push-in member converts the pushing motion into pressing force that secures the face-abutment connection between column and probe without requiring manual dexterity in narrow spaces.
2Ease of operation
If the column and ionization probe are integrated, then the connection issue is eliminated, but the column cannot be removed for adjustment
Solution Approach 1:
The patent segments the connection system into three independent components: the column, the connection jig, and the ionization probe. This segmentation allows the column to be easily detached from the probe by removing the jig, while the jig itself provides the easy connection mechanism through its pressing portion. The segmented design maintains both ease of operation and adaptability.
3Ease of operation
If a dead volume exists in the flow path between column outlet and probe inlet, then the connection is easier, but component diffusion occurs
Solution Approach 1:
The patent replaces the conventional threaded mechanical connection system with a face-abutment pressing mechanism. The pressing portion of the push-in member directly presses the column outlet end face against the probe inlet end face, creating a seal that eliminates dead volume without requiring complex threading operations. This mechanical substitution achieves both ease of operation and precision.
Data Source
AI summary
An ionization probe connection jig used to connect an outlet-side flow path of a column 113 and an inlet-side flow path of an ionization probe 211 in a liquid chromatograph, the ionization probe connection jig includes: a first element fixture 10 fixed to a first element 113 that is one of the column 113 and the ionization probe 211; a second element fixture 20 fixed to a second element 211 that is the other; and a movement regulating tool 30 that permits the first element fixture 10 to advance in an axial direction of the first element 113 while regulating the first element 113 or the first element fixture 10 and the second element 211 or the second element fixture 20 such that flow paths of the first element 113 and the second element 211 are matched with each other, and regulates the second element fixture 20 such that the second element fixture 20 does not retreat beyond a predetermined position in a axial direction of the second element 211.