Iron Dextran Injection with Vitamins for Anemia

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Solution Overview

Problem

Current injectable iron supplements lack biologically active substances, leading to increased toxicity and reduced iron assimilation, and existing oral formulations are ineffective in severe cases of iron deficiency anemia, requiring prolonged administration.

Innovation Solution

A stable injectable iron oxide/hydroxide molecular complex with dextran, containing vitamins like folic acid, vitamin B12, and vitamin E, is developed, with ultrafiltration to reduce free iron ions below 0.05%, ensuring physicochemical stability and enhanced iron assimilation and hematopoiesis promotion.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If parenteral iron formulations are administered to quickly achieve high iron concentrations in the blood, then iron deficiency anemia is treated effectively, but toxic effects occur including reduced blood antioxidant status and dysfunctions of blood organs and liver

Engineering Contradiction:

Improveiron absorption rateVSAvoidtoxicity

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

Vitamin E acts as an intermediary substance that mediates between iron and the body's antioxidant systems. It protects against iron-induced oxidative damage while allowing iron to perform its hematopoietic function, thus resolving the contradiction between effective iron delivery and toxicity reduction

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates a composite formulation combining iron dextran complex with vitamin E and other vitamins. This composite approach allows the iron component to provide rapid iron repletion while the vitamin components provide protective and synergistic effects, reducing toxicity while maintaining high productivity

Inventive Principle:

Principle #40Composite materials

2Productivity

If injectable iron dextran complexes are used to treat severe iron deficiency anemia, then rapid iron repletion is achieved, but iron assimilation is reduced due to lack of biologically active substances

Engineering Contradiction:

Improveiron repletion speedVSAvoidiron assimilation efficiency

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The invention merges iron dextran complex with vitamins (E, B1, B2, B6, B12, folic acid) into a single injectable formulation. This combination ensures that iron is delivered rapidly while simultaneously providing the biologically active substances needed for efficient iron assimilation and utilization in hematopoiesis

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The multifunctional formulation serves multiple purposes: iron dextran provides rapid iron repletion, vitamin E provides antioxidant protection and enhances iron utilization, and B vitamins support hematopoietic function. This multi-functionality resolves the contradiction between speed and efficiency

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Reliability

If oral iron formulations containing vitamins are used for iron deficiency anemia, then iron assimilation is improved, but administration time is prolonged and effectiveness is reduced in severe cases

Engineering Contradiction:

Improveiron assimilation efficiencyVSAvoidtreatment duration

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The invention extracts the beneficial vitamin components from oral formulations and combines them with iron in an injectable form. This allows the patient to receive both the iron and the assimilation-enhancing vitamins simultaneously through a single parenteral administration, eliminating the prolonged treatment duration of oral formulations while maintaining high assimilation efficiency

Inventive Principle:

Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution provides high efficacy in treating iron deficiency anemia with reduced toxicity and improved iron assimilation, as demonstrated by significant increases in hemoglobin, hematocrit, and red blood cell counts, while maintaining vitamin stability and reducing oxidative toxicity.

Implementation Method 1

ultrafiltration to reduce free iron ions below 0.05%

Methodology Applied

Scientific EffectUltrafiltration: Semipermeable Membrane

Implementation Method 2

reducing oxidative toxicity

Methodology Applied

Scientific EffectAntioxidant effect: Oxidation

Data Source

PatentEP3459550B1Injection composition comprising an iron dextran complex and vitamins for preventing and treating anemia

Publication Date: 2021.07.07 OBSHCHESTVO S OGRANICHENNOJ OTVETABTVENNOSTJU VIK ZDOROVE ZHIVOTNYKH

AI summary

The invention relates to medicine and veterinary medicine and can be used to prevent and treat iron deficiency anemia and to promote hematopoiesis. The invention discloses, ready to use an injectable composition for the prevention and treatment of iron deficiency anemia an injectable composition for preventing and treating iron deficiency anemia, containing an iron complex with dextran, where iron complex with dextran is an iron (III) and dextranheptonic acid or an iron (III) oligomaltoside as an active ingredient, and a solvent, wherein the composition additionally contains folic acid and a pH adjuster to pH within 6.0-8.0 with the following contents of the components, wt.%: - iron complex with dextran - 0.5-20.0; - folic acid - 0.1-4.0; - pH adjuster- 0.5-6.0; - solvent - the rest; wherein iron complex with dextran contains free iron ions lower than or equal to 0.05%.