Iron Ion Self-Assembled Complex for Sustained Drug Delivery
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Solution Overview
Problem
Conventional drug delivery systems using synthetic materials and metal ions are toxic and lack sustained release capabilities, limiting their effectiveness and duration of action, and fail to efficiently target desired sites within the body.
Innovation Solution
A self-assembled complex containing an iron ion and a ligand that can reversibly assemble and disassemble, allowing for controlled release of active ingredients over a prolonged period, potentially up to 90 days, using natural substances like adenosine, guanosine, and doxorubicin, and exhibiting paramagnetic properties for targeted delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional synthetic materials and metal ions are used in drug delivery systems, then the structural stability and delivery capability are improved, but the toxicity to the human body increases
Solution Approach 1:
The patent changes the chemical composition parameters by using natural substances (adenosine, guanosine, uridine, cytidine) instead of synthetic materials, and uses iron ions with controlled concentrations (1:1 to 5:1 molar ratio with ligands) to achieve both delivery capability and reduced toxicity
Solution Approach 2:
The patent creates a composite self-assembled complex structure consisting of iron ions coordinated with natural ligands (ATP, ADP, AMP, nucleic acids), forming a new material system that combines the stability of metal complexes with the biocompatibility of natural substances
2Quantity of substance
If conventional drug delivery systems are used, then the initial drug delivery is achieved, but the sustained release capability over prolonged periods is insufficient
Solution Approach 1:
The patent introduces dynamic self-assembly and self-disassembly properties to the drug delivery system. The iron ion-ligand complexes can reversibly assemble and disassemble in response to environmental conditions (pH, temperature, biological enzymes), enabling the system to adapt its structure and control drug release timing and rate over extended periods
Solution Approach 2:
The patent utilizes changes in environmental parameters (pH changes in different body compartments, temperature variations, presence of specific enzymes) to trigger controlled disassembly of the self-assembled complex, thereby releasing the encapsulated drug in a sustained and controlled manner over 1-90 days
3Productivity
If conventional drug delivery systems are used, then short-term drug delivery is achieved, but the targeted delivery to specific sites and sustained efficacy are limited
Solution Approach 1:
The patent replaces passive mechanical delivery systems with a chemically active system that uses coordination chemistry between iron ions and ligands. The reversible coordination bonds allow the system to respond to biochemical signals in the body, enabling active targeting and prolonged efficacy through controlled assembly-disassembly cycles
Solution Approach 2:
The self-assembled iron ion complex serves multiple functions simultaneously: it acts as a drug carrier, a targeting agent (through paramagnetic properties for magnetic guidance), a contrast agent for imaging, and a controlled release system, thereby improving both delivery efficiency and sustained efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the controlled and sustained release of active ingredients to specific sites within the body, reducing toxicity and improving efficacy by using reversible self-assembly and self-disassembly mechanisms, while also allowing for magnetic targeting and use as a contrast agent or artificial bone material.
Implementation Method 1
the iron ion and the ligand are reversibly self-assembled or self-disassembled
Implementation Method 2
exhibiting paramagnetic properties for targeted delivery
Data Source
AI summary
Disclosed is a self-assembled complex containing an iron ion that includes an iron ion; and at least one ligand, where the iron ion and the ligand are reversibly self-assembled or self-disassembled. The iron ion and the ligand are self-assembled to form an assembly structure at least part of which is round shaped.