Ischaemia-Free Organ Perfusion Device for Continuous Normothermic Blood Supply
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Solution Overview
Problem
Current organ transplantation techniques suffer from ischemia-reperfusion injury due to interrupted blood supply during organ acquisition, preservation, and implantation, leading to poor prognosis and organ dysfunction.
Innovation Solution
An ischaemia-free organ perfusion device and method that maintains uninterrupted blood supply using a system of containers, pumps, and flow paths to simulate normothermic machine perfusion, ensuring continuous perfusion from donor to recipient, incorporating features like oxygenators, unidirectional valves, and monitoring systems to regulate perfusion parameters.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If low temperature preservation is used to preserve isolated organs, then organ preservation is achieved, but blood supply is completely interrupted causing ischemia-reperfusion injury
Solution Approach 1:
The patent implements continuous blood supply through normothermic machine perfusion, where blood flows continuously through the organ's vascular system without interruption. The perfusion system maintains continuous circulation from the donor organ through the perfusion device to the recipient, eliminating the ischemic periods that occur with traditional low-temperature preservation and subsequent reimplantation.
Solution Approach 2:
The patent changes the temperature parameter from low temperature (4°C) to normothermic temperature (37°C) during organ preservation and perfusion. This temperature parameter change allows the organ to maintain its metabolic functions and blood flow characteristics, preventing ischemia-reperfusion injury while extending preservation duration.
2Productivity
If traditional organ transplantation is used, then organ acquisition and implantation are achieved, but blood supply is interrupted multiple times causing repeated ischemia attacks
Solution Approach 1:
The patent establishes a continuous perfusion system that maintains blood flow throughout the entire transplantation process. The perfusion device is designed with multiple flow paths that keep blood circulating through the organ continuously, from acquisition through preservation to implantation, eliminating the repeated ischemic attacks that occur when the organ is removed from and reconnected to the circulatory system multiple times.
3Reliability
If normothermic machine perfusion is used for isolated organ preservation, then organ ischemia during preservation is solved, but blood supply interruption occurs during acquisition and implantation processes
Solution Approach 1:
The patent designs a multi-functional perfusion system that can operate in multiple modes: during organ acquisition from the donor, during isolated organ preservation, and during the implantation process. The same perfusion device and flow paths are used for all three stages, providing universal blood supply support throughout the entire transplantation workflow without requiring separate systems for each phase.
Solution Approach 2:
The patent establishes blood supply connections and initiates perfusion before the organ is completely isolated from the donor. The flow paths are pre-configured and blood flow is maintained continuously from the donor's circulatory system through the perfusion device, ensuring that blood supply is never interrupted during the acquisition or implantation processes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively prevents ischemia-reperfusion injury, improving organ viability and transplantation outcomes by maintaining stable blood supply and perfusion pressure, reducing organ damage and improving long-term survival rates.
Implementation Method 1
a first pump configured for flowing the perfusate from the first port to the first perfusion port, and a second pump configured for flowing the perfusate from the first port to the second perfusion port
Implementation Method 2
incorporating features like oxygenators, unidirectional valves, and monitoring systems to regulate perfusion parameters
Data Source
AI summary
Disclosed is an ischaemia-free organ perfusion device and perfusion method. The perfusion device perfuses an isolated organ at normal temperature during whole transplantation, and comprises a first container, a second container, a first flow path, a second flow path, a third flow path and a fourth flow path. The perfusion device and the perfusion method are capable of maintaining the blood flow of the isolated organ during whole transplantation without interruption by machine perfusion, recovering the blood of the organ, effectively avoiding the interruption of blood supply for the organ during the whole transplantation, and improving the prognosis of organ transplantation.