Salts and solid forms of (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same
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Solution Overview
Problem
Current cancer therapies and treatments for diseases associated with undesired angiogenesis are plagued by significant side effects, toxicity, and drug resistance, making them ineffective or refractory in many cases.
Innovation Solution
Development of salts and solid forms of a compound of formula (I) or its stereoisomers, which can be used to create pharmaceutical compositions that effectively treat, prevent, and manage various disorders by controlling angiogenesis or inhibiting cytokine production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cancer therapies are used, then tumor cells can be eradicated, but significant side effects and toxicity occur
Solution Approach 1:
The patent changes the chemical parameters of the therapeutic agent by developing novel salt forms and solid forms of compound (I). These parameter changes in molecular structure and physical state improve the drug's pharmacokinetic properties, reducing toxicity while maintaining anti-cancer effectiveness through optimized solubility, stability, and bioavailability
Solution Approach 2:
The patent creates composite pharmaceutical compositions by combining compound (I) with various pharmaceutically acceptable salts, excipients, and formulation components. These composite materials provide improved therapeutic index by separating the anti-cancer activity from toxic side effects through optimized formulation design
2Reliability
If conventional chemotherapeutic agents are administered, then neoplastic cells can be inhibited, but drug resistance develops
Solution Approach 1:
The patent introduces parameter changes in the chemical structure through salt formation and solid form development, creating novel derivatives with improved biological properties. These structural modifications enable the compound to overcome drug resistance mechanisms by altering molecular recognition, transport, and metabolic pathways while maintaining target engagement
3Reliability
If surgery is performed to remove neoplastic tissue, then cancer can be treated, but the procedure may be contraindicated due to patient health or age
Solution Approach 1:
The patent replaces mechanical surgical intervention with chemical therapy using compound (I) and its salts. This substitution allows treatment of patients who are not surgical candidates due to health constraints or advanced age, providing a non-invasive alternative that achieves similar therapeutic outcomes through pharmacological rather than mechanical means
4Reliability
If radiation therapy is applied, then neoplastic tissue can be targeted, but serious side effects are elicited
Solution Approach 1:
The patent replaces physical radiation therapy with chemical compound (I) administration. This substitution achieves tumor control through biochemical mechanisms rather than ionizing radiation, thereby eliminating radiation-induced side effects while maintaining therapeutic efficacy against neoplastic cells
Data Source
AI summary
Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methos of using the salts and solid forms are also disclosed.