Isoindolinone-Piperidinedione Salts and Solid Forms for Drug Stability
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Solution Overview
Problem
Current cancer treatments, including surgery, chemotherapy, radiation, and hormonal therapy, pose significant drawbacks such as toxicity, side effects, and drug resistance, while treatments for diseases associated with undesired angiogenesis are difficult to manage effectively, and existing pharmaceutical compounds lack optimal stability and bioavailability due to varying solid forms and salt properties.
Innovation Solution
Development of salts and solid forms of the compound (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, including various stereoisomers, hydrates, anhydrates, and solvates, which are characterized by unique physical properties for improved pharmaceutical performance and stability, and their use in pharmaceutical compositions for treating and preventing disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cancer treatments (surgery, chemotherapy, radiation, hormonal therapy) are used, then cancer can be treated, but toxicity and side effects increase
Solution Approach 1:
The patent changes the chemical parameters of the treatment agent by developing novel salt forms and solid forms of compound (I). These parameter changes in the pharmaceutical composition enable effective cancer treatment while reducing toxicity and side effects compared to conventional therapies.
Solution Approach 2:
The patent creates composite pharmaceutical compositions by combining compound (I) with various salts and solid forms. These composite materials provide improved therapeutic index, maintaining cancer treatment effectiveness while minimizing harmful effects on healthy tissues.
2Reliability
If existing pharmaceutical compounds are used, then treatment can be provided, but stability and bioavailability are insufficient due to varying solid forms and salt properties
Solution Approach 1:
The patent systematically changes the physical and chemical parameters of the pharmaceutical compound by establishing specific salt forms and solid forms of compound (I). These parameter changes optimize stability and bioavailability, ensuring reliable treatment effectiveness.
Solution Approach 2:
The patent utilizes solvation and hydration principles (analogous to fluid interactions) by developing solvates and hydrates of compound (I). These forms improve pharmaceutical stability and bioavailability through controlled interaction with solvent molecules in the solid state.
Data Source
AI summary
Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methods of using the salts and solid forms are also disclosed.