Isolator Sterilization Gas Removal Using Internal Catalyst Circulation

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing isolators for handling pathogens and cell preparation require longer sterilization times, which affects work efficiency and sterility assurance levels, despite efforts to shorten the sterilization process by raising temperature and supplying sterilization gas.

Innovation Solution

An isolator design incorporating circulation fans, HEPA filters, and sterilization gas-removing catalysts in both air supply and exhaust units to circulate and adsorb sterilization gas within the isolator, reducing catalyst resistance and shortening sterilization time.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If sterilization gas is supplied to the work room to perform sterilization, then sterility assurance level is secured, but sterilization time becomes long

Engineering Contradiction:
Improvesterility assurance levelVSAvoidsterilization time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent introduces a catalyst as an intermediary substance that facilitates the decomposition of sterilization gas. The catalyst enables the sterilization process to be more efficient by accelerating the chemical reactions involved, thereby reducing the time required to achieve the desired sterility assurance level without compromising effectiveness

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the physical and chemical parameters of the sterilization process by controlling temperature, gas concentration, and catalyst activity. By optimizing these parameters, the sterilization process achieves faster decomposition of the sterilization gas while maintaining the required sterility assurance level, thus reducing overall sterilization time

Inventive Principle:
Principle #35Parameter changes

2Productivity

If circulation fan supplies clean air through HEPA filter, then work efficiency is improved, but device complexity increases

Engineering Contradiction:
Improvework efficiencyVSAvoidair supply unit complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The air supply unit is designed to perform multiple functions: filtering air through HEPA filters, circulating air through the work room, and facilitating sterilization gas decomposition. By integrating these functions into a single system, the patent reduces overall device complexity while maintaining improved work efficiency

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The air supply unit is divided into functional modules (filtration module, circulation module, and catalyst interaction module). This segmentation allows for easier maintenance and operation while achieving the desired work efficiency through coordinated operation of each module

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The isolator achieves faster sterilization with improved work efficiency and secure sterility assurance levels by circulating sterilization gas through internal catalysts, preventing gas leakage and reducing power consumption.

Implementation Method 1

causing an air supply fan to supply the clean air into the isolator, when work is performed. When a sterilization gas is removed, the air supply unit is configured such that the air supply fan circulates the air inside the isolator through a sterilization gas-removing catalyst

Methodology Applied
Scientific EffectAdsorption: Adsorption

Data Source

PatentUS12459140B2Isolator and method for sterilizing same
Publication Date: 2025.11.04 HITACHI IND EQUIP SYST CO LTD
  • US12459140B2 patent drawing
  • US12459140B2 patent drawing
  • US12459140B2 patent drawing

AI summary

There is provided an isolator that is capable of improving work efficiency by shortening a sterilization time, and that is capable of securing a sterility assurance level. An isolator, in which a circulation fan above a work room supplies clean air to the work room via a HEPA filter, includes: the work room; a front door provided in a front surface of the work room; a glove provided in the front door; and an air supply unit that causes an air supply HEPA filter to clean air taken in from an air supply airtight damper, and that causes an air supply fan to supply the clean air into the isolator, when work is performed. When a sterilization gas is removed, the air supply unit is configured such that the air supply fan circulates the air inside the isolator through a sterilization gas-removing catalyst.