Isosorbide Diester Solvents for Non-Cornified Tissue
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Solution Overview
Problem
Conventional solvents for solid cosmetic actives in personal care compositions often fail to maintain solubility across varying conditions and can be irritating to non-cornified epithelial tissues, posing challenges in formulating effective and dermatologically acceptable products.
Innovation Solution
The use of isosorbide diesters as solvents, which are capable of solubilizing solid cosmetic actives and maintaining their stability across a range of conditions, while being dermatologically acceptable for both cornified and non-cornified epithelial tissues, is proposed. These diesters are incorporated into personal care compositions, including skin and hair care products, and can be formulated into emulsions for enhanced application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional solvents are used to solubilize solid cosmetic actives, then solubility is achieved, but the solvents cause irritation to non-cornified epithelial tissues
Solution Approach 1:
The patent changes the chemical parameters of the solvent system by using isosorbide diester instead of conventional solvents. This parameter change maintains the ability to solubilize solid cosmetic actives while fundamentally altering the solvent's interaction with non-cornified epithelial tissues, thereby eliminating irritation.
Solution Approach 2:
The patent replaces conventional solvents with isosorbide diester, which is derived from renewable resources (sorbitol from cornstarch). This substitution uses a biodegradable, naturally-derived solvent that provides the necessary solubility function without the harmful persistent effects of traditional solvents on sensitive tissues.
2Stability of the object's composition
If conventional solvents are used to maintain solubility across varying conditions, then solubility stability is achieved, but dermatological acceptability is compromised
Solution Approach 1:
The isosorbide diester serves multiple functions: it acts as a solvent for solid cosmetic actives, maintains solubility stability across varying conditions, and simultaneously provides dermatological safety for sensitive non-cornified epithelial tissues. This multi-functionality resolves the contradiction between stability and acceptability.
Solution Approach 2:
The patent uses isosorbide diester, a composite molecule derived from the esterification of sorbitol (a polyol from renewable resources), which combines the solubility properties needed for cosmetic actives with the biocompatibility required for sensitive tissue contact, achieving both stability and dermatological acceptability.
3Reliability
If solid cosmetic actives are used directly, then efficacy is improved, but solubility and stability are compromised
Solution Approach 1:
The isosorbide diester acts as an intermediary substance that enables the delivery of solid cosmetic actives. It mediates between the solid active ingredient and the application medium, providing the necessary solubility and stability while maintaining the cosmetic active's efficacy when properly formulated.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Isosorbide diesters effectively solubilize solid cosmetic actives, maintaining stability and dermatological acceptability, thus addressing the limitations of conventional solvents and providing effective skin and hair care benefits without irritation.
Implementation Method 1
The personal care composition comprises an isosorbide diester and a solid cosmetic active soluble in the isosorbide diester
Data Source
AI summary
Compositions for treating non-cornified epithelial tissue of a female body, such as the labia, introitus, and the vagina are disclosed. Methods of regulating dryness in these tissues are also disclosed.