Isosorbide Ester Derivatives Protecting Endothelial ATP

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Solution Overview

Problem

Current solutions for addressing venous system dysfunctions and vascular permeability alterations, such as dark circles and heavy legs, primarily focus on masking symptoms rather than treating the underlying causes, and existing treatments may induce vasodilatation imbalances or have cosmetic drawbacks like unnatural appearances and skin drying.

Innovation Solution

Development of new ester derivatives of N-acyl amino acids, specifically isosorbide esters, to prevent ATP reduction in endothelial cells under oxidative stress, thereby addressing the root cause of venous system dysfunctions and vascular permeability issues, including the formulation of cosmetic compositions containing these esters for topical application.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If existing treatments for venous system dysfunctions are applied, then visible symptoms like dark circles and heavy legs are masked, but the underlying causes remain untreated and treatments may induce vasodilatation imbalances or cause skin drying

Engineering Contradiction:

Improvesymptom maskingVSAvoidvasodilatation balance

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

Instead of masking symptoms externally, the invention inverts the approach by treating the root cause internally through ATP protection in endothelial cells. The esters prevent ATP reduction that leads to venous dysfunction, thereby addressing the problem from its origin rather than its manifestation.

Inventive Principle:

Principle #13The other way round (Inversion)

Solution Approach 2:

The ester derivatives act as intermediary substances that protect ATP in endothelial cells from oxidative stress. These compounds mediate between the external environment and the cellular energy systems, preventing damage without directly causing vasodilatation or affecting skin appearance.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Illumination intensity

If cosmetic products are used to mask venous dysfunction symptoms, then appearance is improved temporarily, but the treatments have drawbacks like unnatural appearances and skin drying

Engineering Contradiction:

Improveskin appearanceVSAvoidskin drying

Core Design Contradiction:

Illumination intensityVSObject-affected harmful factors

Solution Approach 1:

The invention enables the body's own cellular systems to combat venous dysfunction through ATP protection. The esters facilitate the endothelial cells' natural energy production and protection mechanisms, allowing the body to self-correct the dysfunction without external masking or harmful cosmetic interventions.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The invention converts the harmful effect of oxidative stress on ATP into a beneficial protective mechanism. By preventing ATP reduction, the esters transform the vulnerability of endothelial cells to oxidative damage into a targeted protection system that specifically addresses venous dysfunction without side effects.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The ester derivatives effectively prevent and treat ATP reduction in endothelial cells, reducing inaesthetic effects like dark circles and heavy legs by stabilizing vascular function without the drawbacks of existing treatments, offering a balanced and cosmetic-friendly solution.

Implementation Method 1

prevent ATP reduction in endothelial cells under oxidative stress

Methodology Applied

Scientific EffectOxidative stress: Oxidation

Data Source

PatentUS9062069B2Esters of N-acylated derivatives of amino acids and isosorbide, method for preparing same, and use thereof in cosmetics and as drug

Publication Date: 2015.06.23 SOC DEXPLOITATION DE PROD POUR LES IND CHEM SEPPIC

AI summary

Compound with formula (I), wherein R′ and R″ represent a hydrogen atom, a monovalent radical with formula (IIa), or a monovalent radical with formula (IIb), it being understood that at least one of the R′ or R″ radicals does not represent a hydrogen atom and that when the R′ and R″ radicals do not represent a hydrogen atom, R′ and R″ are identical; method for preparing and using in cosmetics and as a drug.