Isosorbide Ether Derivatives for Stable Preservative Systems
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Solution Overview
Problem
Existing preservatives, especially those with ester functions, have limited storage stability and low antimicrobial activity, requiring high concentrations that can cause undesired side effects in compositions like detergents and cosmetics.
Innovation Solution
The use of specific isosorbide ether derivatives with defined structures enhances antimicrobial activity and storage stability, either as standalone preservatives or boosters for existing preservatives, effectively inhibiting a wide range of microorganisms at lower concentrations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If known ester function containing preservatives are used, then antimicrobial activity is achieved, but storage stability deteriorates and side effects increase due to required high concentrations
Solution Approach 1:
The patent changes the chemical structure parameters of preservatives by using isosorbide derivatives with specific alkyl chains (C8-C12) instead of traditional ester-based preservatives. This structural parameter change enables both high antimicrobial activity and excellent storage stability, resolving the contradiction between effectiveness and stability.
Solution Approach 2:
The patent employs composite preservative systems combining isosorbide derivatives with other compatible substances to achieve synergistic effects. This composite approach enhances antimicrobial activity while maintaining storage stability, allowing lower concentrations to be used and reducing side effects.
2Reliability
If high concentrations of antimicrobial preservatives are used to achieve sufficient antimicrobial activity, then microbial inhibition is improved, but undesired side effects increase
Solution Approach 1:
By changing the chemical parameters to isosorbide derivatives with specific molecular structures, the patent achieves high antimicrobial activity at lower concentrations (MIC values indicating potent activity), thereby reducing the harmful side effects associated with high concentrations of traditional preservatives.
3Reliability
If ester function containing preservatives are used, then some preservative activity is achieved, but storage stability deteriorates due to instability of ester functions
Solution Approach 1:
The patent fundamentally changes the chemical functional groups from unstable ester functions to stable ether and hydroxyl groups in isosorbide derivatives. This parameter change eliminates the storage stability issues associated with ester hydrolysis while maintaining effective preservative activity through the unique molecular structure of isosorbide derivatives.
Data Source
AI summary
Isosorbide mono ether derivatives with preservation activity.