Isosorbide Monoesters as Broad pH Antimicrobial Preservatives
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing preservatives used in industries such as cosmetics, pharmaceuticals, and crop protection are often expensive and require high concentrations for effective microbial protection, and many are based on synthetic materials, lacking efficacy across a broad pH range.
Innovation Solution
The use of isosorbide monoesters with specific alkyl or alkenyl groups as antimicrobially active compounds, which are more cost-effective, based on renewable raw materials, and exhibit broad-spectrum preservative performance, including fungicidal activity across a wider pH range compared to organic acids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional preservatives are used, then microbial protection is achieved, but production cost increases and synthetic raw materials are required
Solution Approach 1:
The patent changes the chemical structure parameters by using isosorbide monoesters with specific fatty acid chains (C6-C18) instead of conventional preservatives. This structural parameter change enables renewable raw material usage while maintaining antimicrobial efficacy, thereby reducing production cost and eliminating synthetic material dependence without compromising microbial protection
Solution Approach 2:
The invention employs composite material structure by combining isosorbide core with various fatty acid esters to create a family of compounds with enhanced antimicrobial properties. This composite approach allows leveraging the natural antimicrobial characteristics of fatty acids while using renewable isosorbide backbone, achieving both cost reduction and effective microbial protection
2Reliability
If high concentrations of preservatives are used, then satisfactory preservation is achieved, but cost and formulation complexity increase
Solution Approach 1:
The patent changes the antimicrobial activity parameter of the preservative compounds through specific molecular structure design. The isosorbide monoesters with C6-C18 fatty acids exhibit inherently higher antimicrobial activity compared to conventional preservatives, enabling effective preservation at lower concentrations and reducing both material costs and formulation complexity
3Ease of manufacture
If organic acids are used as preservatives, then cost is reduced, but pH range activity is limited
Solution Approach 1:
The invention changes the chemical parameter of pH range by using isosorbide monoesters that maintain antimicrobial activity across a broader pH spectrum compared to organic acids. The ester structure provides enhanced stability and activity both at low pH (3.5-6) and higher pH levels, making the preservative adaptable to diverse formulation pH requirements while maintaining cost-effectiveness through renewable raw materials
Data Source
AI summary
The use of one or more compounds of the formula (I)in whichR is a straight-chain or branched saturated alkyl group having 5 to 11 carbon atoms or a straight-chain or branched mono- or polyunsaturated alkenyl group having 5 to 11 carbon atomsas antimicrobially active compound is described.The use is preferably in cosmetic, dermatological or pharmaceutical compositions, in crop protection formulations, in washing or cleaning compositions or in paints or coatings.